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ISRN Gastroenterology
Volume 2012 (2012), Article ID 595734, 7 pages
http://dx.doi.org/10.5402/2012/595734
Research Article

Thyroid and Hepatic Haemodynamic Alterations among Egyptian Children with Liver Cirrhosis

1Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo 11371, Egypt
2Department of Radiology, Faculty of Medicine, Ain Shams University, Cairo 11371, Egypt
3Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo 11371, Egypt

Received 3 April 2012; Accepted 18 June 2012

Academic Editors: M. Kairaluoma, T. Okumura, and W. Vogel

Copyright © 2012 Zeinab A. El-Kabbany et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Alterations in thyroid hormones regulation and metabolism are frequently observed in patients with cirrhosis. Aims. To assess alterations in thyroid volume (TV), haemodynamics, and hormones in patients with cirrhosis and their relation to hepatic arterial haemodynamics, and disease severity. Methods. Forty cirrhotic patients were compared to 30 healthy subjects regarding TV, free triiodiothyronine (fT3), free tetraiodothyronine (fT4), thyroid stimulating hormone (TSH), and pulsatility and resistance indices in the inferior thyroid and hepatic arteries. Results. TV ( 𝑃 = 0 . 0 4 2 ), thyroid volume standard deviation score (TVSDS, 𝑃 = 0 . 0 0 1 ), Inferior Thyroid Artery Pulsatility Index (ITAPI, 𝑃 = 0 . 0 0 1 ), Inferior Thyroid Artery Resistance Index (ITARI, 𝑃 = 0 . 0 4 1 ), Hepatic Artery Pulsatility Index (HAPI, 𝑃 = 0 . 0 2 9 ) and Hepatic Artery Resistance Index (HARI, 𝑃 = 0 . 0 3 5 ) were higher among cases being highest in Child-C patients. FT3 was lower in patients than controls ( 𝑃 = 0 . 0 0 1 ) and correlated negatively with ITAPI ( 𝑟 = 0 . 7 1 , 𝑃 = 0 . 0 2 1 ) and ITARI ( 𝑟 = 0 . 7 9 , 𝑃 = 0 . 0 1 1 ). ITAPI and ITARI correlated directly with HAPI and HARI ( 𝑟 = 0 . 6 2 , 𝑃 = 0 . 0 3 , and 𝑟 = 0 . 4 2 , 𝑃 = 0 . 0 4 , resp.). Conclusions. Thyroid is involved in the haemodynamic alterations of cirrhosis. Routine study of thyroid by Doppler and assessment of thyroid functions should be performed in patients with cirrhosis to offer proper treatment if needed.