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ISRN Gastroenterology
Volume 2012 (2012), Article ID 706937, 6 pages
http://dx.doi.org/10.5402/2012/706937
Clinical Study

Subclinical Cardiac Dysfunction in Children with Coeliac Disease: Is the Gluten-Free Diet Effective?

1Department of Pediatric Cardiology, Faculty of Medicine, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey
2Department of Pediatric Cardiology, Faculty of Medicine, Gazi University, 06500 Ankara, Turkey
3Department of Pediatric Gastroenterology, Ankara Diskapi Children's Hospital, 06110 Ankara, Turkey
4Department of Pediatric Cardiology, Ankara Diskapi Children's Hospital, 06110 Ankara, Turkey
5Department of Biostatistics and Medıcal Informatics, Faculty of Medicine, Akdeniz University, 07059 Antalya, Turkey
6Department of Pediatric Gastroenterology, Faculty of Medicine, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey

Received 21 August 2012; Accepted 2 October 2012

Academic Editors: G. Barbaro, L. Murray, and L. Rodrigo

Copyright © 2012 Berna Saylan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. The aim of this study is to investigate the effects of coeliac disease on cardiac function in children using conventional transthoracic echocardiography (TTE) and tissue Doppler echocardiography (TDE). Methods. Coeliac disease patients were evaluated in two different groups based on serum endomysial antibody (EmA) titers (EmA (+) and EmA (−)), and the data obtained by conventional and TDE studies were compared between the patient groups and healthy controls. Results. There was no significant difference between EmA (+) and EmA (−) groups in terms of the conventional TTE parameters, including ejection fraction (EF), fractional shortening (FS), and left ventricle end diastolic diameter (LVEDD), that show the left ventricular systolic function ( , , ). TDE showed a significant difference in left ventricle (LV) isovolumic relaxation time (LV IVRT) and LV myocardial performance index (LV MPI) parameters between EmA (+) and EmA (−) patient groups ( ). Conclusion. The measurement of LV MPI and LV IVRT parameters by TDE would be beneficial in early determination of the cardiac involvement and establishing appropriate treatment and followup of patients with coeliac disease as well as in making distinction between EmA (+) and EmA (−) patients.