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ISRN Gastroenterology
Volume 2012 (2012), Article ID 826323, 4 pages
http://dx.doi.org/10.5402/2012/826323
Clinical Study

DNase1: No Association with Crohn's Disease in a New Zealand Population

1Discipline of Nutrition, Faculty of Medical and Health Sciences (FMHS), The University of Auckland, 85 Park Road, Grafton, 1142 Auckland, New Zealand
2Nutrigenomics New Zealand, New Zealand
3Department of Medicine, Faculty of Medical and Health Sciences (FMHS), The University of Auckland, 85 Park Road, Grafton, 1142 Auckland, New Zealand

Received 29 February 2012; Accepted 10 April 2012

Academic Editors: G. Barbaro, J. C. Hoffmann, L. Rodrigo, and I. Takeyoshi

Copyright © 2012 Angharad R. Morgan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigated whether DNase1 SNPs rs1053874 and rs8176938 were associated with CD in a well-characterized New Zealand dataset consisting of 447 cases and 716 controls. Furthermore, we measured serum DNase1 activity levels in a number of CD patients and controls. We did not find any evidence of association for either DNase1 genetic variation or DNase1 activity levels with CD. The lack of association indicates that DNase1 does not play a significant role in predisposing to CD in the New Zealand population.