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ISRN Gastroenterology
Volume 2013 (2013), Article ID 398297, 8 pages
http://dx.doi.org/10.1155/2013/398297
Research Article

The Effect of Weight Loss on Pediatric Nonalcoholic Fatty Liver Disease

1Department of Human Nutrition, Food and Animal Science, University of Hawai’i at Manoa, 1955 East West Road, Agriculture Science 314 J, Honolulu, HI 96822, USA
2Department of Pediatrics, Kapi’olani Medical Center for Women and Children, 1319 Punahou Street, Honolulu, HI 96826, USA

Received 2 April 2013; Accepted 30 April 2013

Academic Editors: A. Nakajima, C.-T. Shun, and A. A. te Velde

Copyright © 2013 David E. St-Jules et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study evaluated the effect of weight loss on pediatric nonalcoholic fatty liver disease (NAFLD). Subjects included 81 overweight NAFLD patients referred to two pediatric gastroenterologists from 2000 to 2010. Data on subjects were obtained from review of medical charts. The effect of weight loss was assessed at 1–4 months, 5–8 months, 9–12 months, and beyond one year as the change in weight, BMI -score (for age-and-sex), and alanine aminotransferase and the relationship between the change in body weight and BMI -score, and the change in alanine aminotransferase. Subjects were mostly obese (99%), male (86%), and Asian (63%) and had median age of 14.1 (11.2–16.2) years and alanine aminotransferase of 105 (78–153) U/L at referral. Alanine aminotransferase decreased 32 ± 66 ( ), 30 ± 65 ( ), 37 ± 75 ( ), and 45 ± 69 ( ) for subjects with follow-up data at 1–4 months ( ), 5–8 months ( ), 9–12 months ( ), and beyond one year ( ), respectively. During these time periods, neither was body weight (−0.2 to +7.1 kg) or BMI -score (−0.12 to −0.05) significantly reduced, nor were changes in these variables associated with the change in alanine aminotransferase. These findings suggest that weight and BMI -score may not be sufficient indicators of treatment response in pediatric NAFLD patients.