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ISRN Materials Science
Volume 2012 (2012), Article ID 608548, 20 pages
http://dx.doi.org/10.5402/2012/608548
Review Article

Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, Centro de Investigación Biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28040 Madrid, Spain

Received 26 June 2012; Accepted 24 July 2012

Academic Editors: M. Leoni and Y. Masuda

Copyright © 2012 María Vallet-Regí. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.