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ISRN Molecular Biology
Volume 2012 (2012), Article ID 856987, 12 pages
http://dx.doi.org/10.5402/2012/856987
Review Article

Regulation of GLUT4 and Insulin-Dependent Glucose Flux

Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P.O. Box 26901, BMSB 964, Oklahoma City, OK 73190, USA

Received 2 September 2012; Accepted 24 September 2012

Academic Editors: A. M. Da Silva and H.-C. Lee

Copyright © 2012 Ann Louise Olson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

GLUT4 has long been known to be an insulin responsive glucose transporter. Regulation of GLUT4 has been a major focus of research on the cause and prevention of type 2 diabetes. Understanding how insulin signaling alters the intracellular trafficking of GLUT4 as well as understanding the fate of glucose transported into the cell by GLUT4 will be critically important for seeking solutions to the current rise in diabetes and metabolic disease.