354262.fig.002a
(a)
354262.fig.002b
(b)
354262.fig.002c
(c)
354262.fig.002d
(d)
Figure 2: Activation of Slack and Slick channels by cytoplasmic sodium. (a) Representative patch of macroscopic Slack currents recorded at 0 and −80 mV in an excised inside-out patch from Slack-transfected CHO cells in the presence and absence of 90 mM sodium. (b) Concentration-response relationship of sodium activation of Slack current in excised patches. Currents were normalized those recorded in 90 mM sodium. (c) Excised patch recording at −80 mV from a CHO cell transfected with Slick. The cytoplasmic face of the patch was perfused with a solution containing either 0 or 50 mM intracellular sodium. (d) Concentration-response relationship of sodium activation of Slick channels in excised patches. Figures modified from [4].