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ISRN Obstetrics and Gynecology
Volume 2012 (2012), Article ID 263871, 6 pages
http://dx.doi.org/10.5402/2012/263871
Clinical Study

PP13 and PAPP-A in the First and Second Trimesters: Predictive Factors for Preeclampsia?

1OB/GYN Department, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran
2Pathology Department, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran
3Education Development Center (EDC), Mazandaran University of Medical Sciences, Sari, Iran

Received 14 March 2012; Accepted 9 April 2012

Academic Editors: G. Rizzo and J. G. Schenker

Copyright © 2012 Narges Moslemi Zadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Preeclampsia affects 5-6% of all pregnancies. Predictive factors of preeclampsia can be helpful in early diagnosis of this disease. In this study the predictive values of biochemical markers placenta protein 13 (PP13) and pregnancy-associated plasma protein A (PAPP-A) have been assessed in early diagnosis of preeclampsia. Methods. This case-control study was conducted on 1500 women who presented to a healthcare center of Sari, Iran, between 2010 and 2011. Blood samples were drawn in weeks 11–13 and 24–28 of pregnancy. Of them who developed preeclampsia were considered as case group. A control group consisted of similar women regarding mean age, body mass index (BMI), and pregnancy age. PAPP-A and PP13 serum levels were measured. Data were analyzed using proper statistical tests. Results. PAPP-A and PP13 serum levels were significantly lower in both the first and second trimesters in women who developed preeclampsia ( 𝑃 < 0 . 0 0 1 ). The cumulative value of all four variables with cut-off point of 238.5 has sensitivity, specificity of 91.0%, and undercurve surface of 0.968 which is the most diagnostic value for preeclampsia. Conclusion. It is possible to advantage measuring of PAPP-A and PP13 in the first and second trimesters especially their cumulative values in both trimesters for prediction of the incidence of preeclampsia.