Table 2: Distribution of studied markers in each group in the first and second trimesters.

MarkersControlMild preeclampsiaSevere preeclampsia 𝐹 factor 𝑃 value

PAPPA first trimester 2 . 7 ± 1 . 4 1 . 7 ± 0 . 4 0 . 9 9 ± 0 . 4 38.0<0.001
PP13 first trimester 1 0 1 . 7 ± 1 6 . 8 8 0 . 5 ± 1 4 . 4 5 4 . 5 ± 1 8 . 9 111.9<0.001
PAPPA second trimester 1 1 3 . 2 ± 1 4 . 3 9 7 . 2 ± 1 6 . 8 9 0 . 0 ± 1 2 . 8 38.8<0.001
PP13 second trimester 3 7 7 . 9 ± 6 9 . 5 2 8 8 . 6 ± 5 5 . 4 2 4 4 . 8 ± 5 7 . 4 75.6<0.001