Table 2: Clinical features and pathology of cases with known bone metastasis PIK3CA mutation status.

CaseBone metastasisPrimaryTime from Time from
PIK3CA
status
ER statusPgR statusHER2 statusER statusPgR statusHER2 statuscancer diagnosis (years)metastatic cancer diagnosis (years)

2E545Kpos.pos.normalpos.pos.normal1111
3WTpos.neg.normalpos.neg.normal111
4H1047Rpos.neg.normalpos.pos.normal142
11WTpos.pos.normalpos.pos.normal2321
12H1047R hom.pos.*neg.*amplified*pos.neg.amplified<1<1
13WTpos.neg.normalpos.pos.normal<1<1

Estrogen (ER) and progesterone (PgR) statuses are shown as positive (pos.) or negative (neg.). Time from cancer diagnosis and metastatic cancer diagnosis is the time between diagnosis and the biopsy taken for this study. *determined from CT-guided bone biopsy; other metastasis receptor and HER2 data are determined from trephine biopsies.