Review Article

Development of Safer Gene Delivery Systems to Minimize the Risk of Insertional Mutagenesis-Related Malignancies: A Critical Issue for the Field of Gene Therapy

Figure 1

This figure shows the first mechanism for cellular oncogene expression, which takes place through transcriptional activation promoter that is mediated by the retroviral 3′-long terminal repeat (LTR). The bent arrows depict the transcription start site of the 5′- and 3′-LTR.
616310.fig.001