Table 1: Patient characteristics ( ): no significant difference in age, KPS, number of brain metastases, extracranial metastases, primary tumour control, DS-GPA and RPA classification, radiation dose, and time interval ( or more); significant difference: primary disease type ( ).

ParameterInterval < 12 daysInterval ≥ 12 days

Median age, years6464
Median KPS6070
Median DS-GPA score (min. 0, max. 4 points)1.01.0
Number of BM: 1 (%)59
Number of BM: 2-3 (%)1716
Number of BM: >3 (%)2527
Extracranial metastases (%)4338
No extracranial metastases (%)515
Uncontrolled primary tumour (%)1625
Controlled primary tumour (%)3128
DS-GPA class I versus II versus III versus IV (%) 2, 4, 9, 331, 5, 17, 30
RPA class I versus II versus III (%)2, 20, 253, 26, 24
NSCLC, SCLC (%)15, 832, 2
Breast, MM, and GI (%)9, 3, 63, 4, 6
Kidney, others (%)4, 24, 3
Total dose 20 Gy (%)1217
Total dose 30 Gy (%)3535
Simultaneous detection of BM and primary tumour (%)817
Time interval to BM 1–12 months (%)2317
Time interval to BM 13–36 months (%)79
Time interval to BM > 36 months (%)98

KPS: Karnofsky performance status; BM: brain metastases; DS-GPA: diagnosis-specific graded prognostic assessment; NSCLC: nonsmall cell lung cancer; SCLC: small cell lung cancer; MM: malignant melanoma; GI: gastrointestinal primary tumour.