Table 2: Patients with grade 3 or 4 toxicity by the NCI Common Toxicity Criteria version 3.0.

CharacteristicsFLOX arm 3-week arm value
Grade IIIGrade IVGrade IIIGrade IV

Diarrhea 4 (16%)1 (4%)4 (16%)1 (4%).11
Dehydration2 (8%)1 (4%).09
Nausea 1 (4%)2 (8%).101
Vomiting 3 (12%)1 (4%).07
Stomatitis 1 (4%)1 (4%)
Hematological
 Neutropenia 1 (4%)1 (4%)
 Anaemia 2 (8%)1 (4%).089
 Thrombocytopenia
Neurosensory 1 (4%)1 (4%)
Thrombosis and embolism1 (4%)1 (4%)
Liver
 Elevated transaminases 2 (8%)3 (4%).21