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ISRN Oncology
Volume 2013 (2013), Article ID 675051, 8 pages
http://dx.doi.org/10.1155/2013/675051
Clinical Study

Cell Proliferation (KI-67) Expression Is Associated with Poorer Prognosis in Nigerian Compared to British Breast Cancer Women

1Department of Morbid Anatomy and Histopathology, Olabisi Onabanjo University, Sagamu, Nigeria
2Specialist Laboratory, Idi-Araba, Lagos, Nigeria
3Department of Surgery, Olabisi Onabanjo University, Sagamu, Nigeria
4Department of Medical Microbiology and Parasitology, Olabisi Onabanjo University, Sagamu, Nigeria
5School of Molecular Medical Science, Oncology Unit, University of Nottingham, Nottingham, UK

Received 25 February 2013; Accepted 14 March 2013

Academic Editors: Y. Akiyama, Z. S. Guo, and Y. Yamamoto

Copyright © 2013 Ayodeji O. J. Agboola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Black women with breast cancer (BC) in Nigeria have higher mortality rate compared with British women. This study investigated prognostic features of cell proliferation biomarker (Ki-67) in Nigerian breast cancer women. Materials and Methods. The protein expression of Ki-67 was investigated in series of 308 Nigerian women, prepared as a tissue microarray (TMA), using immunohistochemistry. Clinic-pathological parameters, biomarkers, and patient outcome of tumours expressing Ki-67 in Nigerian women were correlated with UK grade-matched series. Results. A significantly larger proportion of breast tumours from Nigerian women showed high Ki-67 expression. Those tumours were significantly correlated with negative expression of the steroid hormone receptors (ER and PgR), p21, p27, E-cadherin, BRCA-1, and Bcl-2 (all ), but positively associated with EGFR ( ), p53, basal cytokeratins: CK56, CK14, triple negative, and basal phenotype using Nielsen’s classification (all ) compared to UK women. Multivariate analyses showed that race was also associated with BCSS independent of tumour size, lymph node status, and ER status. Conclusion. Ki-67 expression was observed to have contributed to the difference in the BCSS in Nigerian compared with British BC women. Therefore, targeting Ki-67 in the indigenous black women with BC might improve the patient outcome in the black women with BC.