Table 4: Relationship between biomarker expression in UK and Nigerian tumours expressing KI-67.

VariablesKI-67 positive expression
Nigeria (%)UK (%) 2 valueP value

BRCA1
 Negative 143 (80.8)31 (21.5)112.34<0.001
 Positive 34 (19.2)113 (78.5)
Bcl-2
 Negative101 (57.4)53 (37.6)13.15<0.001
 Positive75 (42.6)88 (62.4)
CK5/6
 Negative108 (58.7)137 (84.6)27.90<0.001
 Positive 76 (41.3)25 (15.4)
CK14
 Negative97 (58.8) 148 (90.8)44.5<0.001
 Positive 68 (41.2)15 (9.2)
ER
 Negative169 (84.5)45 (28.0)118.17<0.001
 Positive31 (15.5)116 (72.0)
EGFR
 Negative119 (66.5)123 (80.4)8.080.003
 Positive 60 (33.5)30 (19.6)
E-cadherin
 Negative119 (73.5)65 (40.1)36.7<0.001
 Positive43 (26.5)97 (59.9)
HER-2
 Negative148 (81.8)140 (87.5)2.130.14
 Positive33 (18.2)20 (12.5)
PgR
 Negative126 (79.7)68 (41.7)48.53<0.001
 Positive32 (20.3)95 (58.3)
p27
 Negative131 (68.9)45 (46.4)13.77<0.001
 Positive 59 (31.1)52 (53.6)
p21
 Negative152 (83.1)65 (61.9)16.07<0.001
 Positive 31 (16.9)40 (38.1)
p53
 Negative1 (1.0)10 (14.7)13.11<0.001
 Positive 104 (99.0)58 (85.3)
P-cadherin
 Negative81 (41.5)66 (44.9)0.380.54
 Positive 114 (58.5)81 (55.1)
Triple negative
 No68 (45.6)128 (79.0)37.10<0.001
 Yes 81 (54.4)34 (21.0)
Classification
 Basal 56 (49.1)15 (10.2)149.02<0.001
 HER-226 (22.8)9 (6.2)
 Luminal A27 (23.7)113 (77.4)
 Luminal B5 (4.4)9 (6.2)