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ISRN Oncology
Volume 2013 (2013), Article ID 697521, 25 pages
http://dx.doi.org/10.1155/2013/697521
Review Article

The Role of Chronic Inflammation in Obesity-Associated Cancers

Department of Pathology and Department of Medical Laboratory Sciences, University of Vermont, Burlington, VT, USA

Received 17 April 2013; Accepted 12 May 2013

Academic Editors: P. Balaram, I. Faraoni, L. Hunakova, P. Karakitsos, and B. Luber

Copyright © 2013 Maria E. Ramos-Nino. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There is a strong relationship between metabolism and immunity, which can become deleterious under conditions of metabolic stress. Obesity, considered a chronic inflammatory disease, is one example of this link. Chronic inflammation is increasingly being recognized as an etiology in several cancers, particularly those of epithelial origin, and therefore a potential link between obesity and cancer. In this review, the connection between the different factors that can lead to the chronic inflammatory state in the obese individual, as well as their effect in tumorigenesis, is addressed. Furthermore, the association between obesity, inflammation, and esophageal, liver, colon, postmenopausal breast, and endometrial cancers is discussed.