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ISRN Oncology
Volume 2013 (2013), Article ID 752792, 6 pages
Research Article

The Predictive Value of Cystatin C in Monitoring of B Non-Hodgkin Lymphomas: Relation to Biochemical and Clinical Parameters

1Department of Biochemistry, Faculty of Pharmacy, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina
2Clinic for Oncology, Haematology and Radiotherapy, University Clinical Centre Tuzla, 75000 Tuzla, Bosnia and Herzegovina
3Chair of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia
4Department of Biotechnology, Jožef Stefan Institute, 1000 Ljubljana, Slovenia

Received 11 July 2013; Accepted 13 August 2013

Academic Editors: G. Gatti and G. E. Kim

Copyright © 2013 A. Softić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The predictive value of cystatin C as a marker of course of the disease has been evaluated. Fifty-two pairs of serum samples of patients with B non-Hodgkin lymphoma have been collected at the time of diagnosis and before fourth cycle of chemotherapy. The levels of cystatin C, CRP, β2M, LDH, and IL-6 in samples have been measured, and clinical parameters of course of the disease (B symptoms, clinical stage, patients’ age, and IPI) have been noted. In total patient’s group cystatin C levels correlated with β2M and IPI. In aggressive lymphomas, the inhibitor levels correlated with clinical stage of disease and were significantly higher in patients with elevated LDH activity. In aggressive nodal lymphomas its levels correlated with β2M, IPI, and clinical stage of disease. The cystatin C level was significantly increased in total group of patients over 60 years old, while in particular types of lymphoma, no statistical significance has been obtained. Our results indicate that cystatin C should be taken into consideration in disease monitoring. However, we expect that the disease-free and overall survival analysis will give the definitive answer about the reliability of cystatin C as an indicator of course of aggressive lymphomas.