687365.fig.002a
(a)
687365.fig.002b
(b)
Figure 2: Population pyramids showing the difference in the predicted cumulative EQD2 (calculated assuming the doses were same in both fractions) from the actual cumulative EQD2. The ordinate axis represents the number of patients while the abscissa represents the percent difference between the hypothetical cumulative EQD2 and the actual cumulative EQD2. (a) and (b) show the population pyramids for bladder and rectum respectively. Grey bars represent the number of patients who had an increase in the actual cumulative EQD2 over that predicted if the dose in each fraction was considered to be same. The frequency of patients in whom the actual EQD2 would have been 10% more than the predicted is represented by the gray bars above the dotted line.