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ISRN Organic Chemistry
Volume 2012 (2012), Article ID 242569, 6 pages
http://dx.doi.org/10.5402/2012/242569
Research Article

ZnO Catalyzed Efficient Synthesis of Some New 2-Substituted-4,6-diarylpyrimidines

Department of Chemistry, Faculty of Arts, Science and Commerce, Mody Institute of Technology & Science, Lakshmangarh 332311, Rajasthan, India

Received 5 September 2012; Accepted 24 September 2012

Academic Editors: G. Gattuso, J. Ishihara, J. L. Jios, and J.-P. Praly

Copyright © 2012 K. L. Ameta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple and efficient protocol is developed for the synthesis of 2-substituted-4,6-diarylpyrimidines from one-pot three-component reaction of 4′-hydroxy-3′,5′-dinitro substituted chalcones, S-benzylthiouronium chloride (SBT), and heterocyclic secondary amines (morpholine/pyrrolidine/piperidine) in the presence of 15 mol% of ZnO as a heterogeneous catalyst. The present methodology offers several advantages such as being a simple procedure as well as providing excellent yields, and short reaction time. The catalyst is inexpensive, stable, and can be easily recycled and reused for several cycles with consistent activity.