Table 1: Summarized data obtained during selection of MSO-Fast and MSO-Slow lines.

MouseStep 𝑛 Latency (min)Seizures (%)Death (%)ED50 (mg/kg)

G0initial343420 ± 1008037ND
MSO-FastG6104320 ± 50881236,1 ± 0,3
MSO-SlowG680570 ± 3055124,9 ± 10,3
MSO-FastC840240 ± 20100641.8 ± 1.6
MSO-SlowC84060002>300

Data concerned sensitivity toward MSO (75 mg/kg) of mouse at different levels of generation during the selection process. G0: after mixing of the eight parental strains, G6: after 6 processes of crossing and MSO-challenging, C8: after 8 inbreeding crossings of the selected lines after 10 MSO-challenges. ND: not determined. Data adapted from Cloix et al. [112].