Table 2: Summarized latency (min) obtained during characterization of MSO-Fast and MSO-Slow lines at the 6th generation of selection process.

ProductsMouse
MSO-Fast 𝑛 MSO-Slow 𝑛

Convulsant
MSO (75 mg/kg) 2 9 5 , 6 ± 1 0 2 , 4 a 20ND
MSO (200 mg/kg)ND 3 4 7 , 7 ± 7 9 , 5 20
KA (25 mg/kg) 4 8 , 8 ± 2 3 , 2 a 28 7 6 , 8 ± 4 6 , 5 27
PTZ (75 mg/kg) 1 , 2 4 ± 0 , 4 8 b 30 1 , 1 8 ± 0 , 4 6 29
Anticonvulsant
MK-801 (1 mg/kg) 6 0 0 c 12 6 0 0 c 12
VPA (250 mg/kg) 4 5 3 , 7 ± 6 5 , 1 d 10 4 7 0 , 5 ± 1 8 3 , 6 10

The anticonvulsants were given to mice 30 minutes before the appropriate dose of MSO. a: P < 0.01 MSO-Fast versus MSO-Slow. b: NS. c: The anticonvulsant effect of MK-801 is obvious, but not statistically analyzed as the latency value in its presence has no SEM. Indeed, when the latency is above 10 hours, mice were given a score of 600. d: P < 0.001 VPA versus its absence in MSO-Fast only. ND: not determined. Data adapted from Cloix et al. [113].