About this Journal Submit a Manuscript Table of Contents
ISRN Pharmaceutics
Volume 2012 (2012), Article ID 230621, 7 pages
http://dx.doi.org/10.5402/2012/230621
Research Article

Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride

1Department of Pharmacy, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim 737136, India
2Bengal College of Pharmaceutical Sciences and Research, Bidhannagar, West Bengal, Durgapur 713212, India

Received 27 March 2012; Accepted 6 June 2012

Academic Editors: J.-J. Chen, J.-M. Huang, and E. Lattmann

Copyright © 2012 Pritam Banerjee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. The objective of the proposed work is to evaluate the efficacy of Pectins to qualify them as polymers for designing an oral microsphere for the delivery of selected oral antidiabetic drug-like metformin hydrochloride. Methods. Different Microspheres formulations were prepared by the water in oil (w\o) emulsion solvent evaporation technique and subsequently evaluated for its different physical parameters as well as its in vitro and in vivo drug release study. Results. The formulations F2 (98.42) and F3 (98.03) showed a constant and high release in the dissolution profile, so among these two formulations, F2 was taken for development study, due to the better result shown over in other evaluation parameters. From the HPLC determinations after in vivo study, it had been found that the test samples and the standard sample had not shown any significant fluctuation in relation to their retention time. Conclusion. From in vitro and in  vivo results, it may be concluded that drug-loaded pectin microspheres in 1 : 1 ratio are a suitable delivery system for metformin hydrochloride and may be used for effective management of NIDDM. From this experiment, it could be concluded that as a natural polymer, pectin has potentiality in novel drug delivery system.