Table 4: Effect of pectin microspheres of metformin HCl on alloxan induced diabetic rats.

Serial numberDesign of controlDrugBlood glucose level mg/dL
0 hr1 hr3 hr5 hr

1Diabetic control304.7 ± 5.2312.3 ± 1.4301.8 ± 3.5318.2 ± 7.1
2Placebo101.2 ± 9.6134.7 ± 7.1137.7 ± 5.8131.9 ± 5.8
3Pure metformin HCl25 mg/kg298.7 ± 6.4134.4 ± 5.3*156.2 ± 7.8*205.3 ± 7.8*
4Pectin microsphere25 mg/kg297.5 ± 13.6206.1 ± 4.3*192.5 ± 5.4*173.1 ± 9.3*

𝑁 = 6 , * 𝑃 < 0 . 0 0 1 versus control, values are expressed as mean ± SEM. *Statistically significant when compared with diabetic controls ( 𝑃 < 0 . 0 5 ).