Research Article

Ondansetron HCl Microemulsions for Transdermal Delivery: Formulation and In Vitro Skin Permeation

Table 1

Compositions of various ondansetron HCl microemulsions and skin permeation fluxes ( 𝜇 g/cm2/hr) through excised porcine skina.

CodesOil (%)Surfactant and cosurfactant (3 : 1)Water (%)Permeation flux
(Tween 80 and isopropyl alcohol, %)( 𝜇 g/cm2/hour)b

Oleic acid
F-12560150.090  ±  0.001
F-22065150.146  ±  0.001
F-31575100.186  ±  0.002
F-4108280.199  ±  0.002
Isopropyl myristate
F-52560150.229  ±  0.002
F-62065150.233  ±  0.002
F-71575100.257  ±  0.003
F-8108280.284  ±  0.003

aAll microemulsions contained 20 mg of ondansetron HCl.
bMean  ±  S.D., n = 3.