Research Article
Ondansetron HCl Microemulsions for Transdermal Delivery: Formulation and In Vitro Skin Permeation
Table 1
Compositions of various ondansetron HCl microemulsions and skin permeation fluxes (g/cm2/hr) through excised porcine skina.
| Codes | Oil (%) | Surfactant and cosurfactant (3 : 1) | Water (%) | Permeation flux | (Tween 80 and isopropyl alcohol, %) | (g/cm2/hour)b |
| | Oleic acid | | | | F-1 | 25 | 60 | 15 | 0.090 0.001 | F-2 | 20 | 65 | 15 | 0.146 0.001 | F-3 | 15 | 75 | 10 | 0.186 0.002 | F-4 | 10 | 82 | 8 | 0.199 0.002 | | Isopropyl myristate | | | | F-5 | 25 | 60 | 15 | 0.229 0.002 | F-6 | 20 | 65 | 15 | 0.233 0.002 | F-7 | 15 | 75 | 10 | 0.257 0.003 | F-8 | 10 | 82 | 8 | 0.284 0.003 |
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aAll microemulsions contained 20 mg of ondansetron HCl.
bMean S.D., n = 3.
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