Review Article

Lipoidal Soft Hybrid Biocarriers of Supramolecular Construction for Drug Delivery

Table 1

Comparison of few aspects of lipoidal particulate carriers and their applications.

S. no.CarrierCompositionEntrapped agentUnique featuresReferences

1LiposomesPhospholipids:cholesterol:alcoholAntibiotics, antineoplastic agents, antitubercular drugsAmphiphilic nature provides solubilization of both hydrophilic and lipophilic drugs, internalisation and amplification of bioactives [20, 21]
2TransfersomesPhospholipids:edge activators:alcohols:buffering agent:dyeNSAIDs, anesthetics, steroidal hormonesUltradeformable vesicles can deform and pass through narrow constriction (from 5 to 10 times less than their own diameter) without measurable loss [2230]
3PharmacosomesPhospholipids:dichloromethaneNSAIDsColloidal dispersions of drugs covalently bound to lipids, which increased entrapment efficiency; no loss of drug due to leakage, no problem of drug incorporation [3133]
4EthosomesPhospholipids:ethanolAntifungal agent, antiviral agent, antikeratinizing agent, NSAIDsCombinational approach of high concentration of ethanol along with phospholipids synergizes effect of deeper distribution and penetration of drugs in the skin[17, 3442]