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ISRN Pharmaceutics
Volume 2012 (2012), Article ID 873653, 8 pages
http://dx.doi.org/10.5402/2012/873653
Research Article

Formulation and In Vitro Evaluation of Ufasomes for Dermal Administration of Methotrexate

Chitkara College of Pharmacy, Chitkara University, Punjab, India

Received 19 March 2012; Accepted 9 April 2012

Academic Editors: K. Cal and M. R. Jaafari

Copyright © 2012 Arvind Sharma and Sandeep Arora. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dermal drug delivery system that is required to localizes methotrexate (MTX) in the synovial joint is needed to treat inflammation in rheumatoid arthritis (RA). The present investigation aims at exploring the potential of fatty acid vesicles for the topical delivery of methotrexate. Vesicles were prepared by film hydration method using oleic acid as a fatty acid principal component. Developed vesicles were characterized for size, size distribution, shape, in vitro release, pH dependent, and storage stability. Interaction between MTX and oleic acid was investigated using differential scanning calorimetry. The MTX amount permeated through rat skin was three- to fourfold higher using oleic acid compared to those from plain drug solution or carbopol gel. At the end of the skin permeation assay using ufasomes, up to 50% of the administered dose was found in the skin. These results suggest that methotrexate encapsulated in oleic acid vesicles may be of value for the topical administration of MTX in the treatment of psoriasis.