About this Journal Submit a Manuscript Table of Contents
ISRN Pharmaceutics
Volume 2012 (2012), Article ID 873653, 8 pages
http://dx.doi.org/10.5402/2012/873653
Research Article

Formulation and In Vitro Evaluation of Ufasomes for Dermal Administration of Methotrexate

Chitkara College of Pharmacy, Chitkara University, Punjab, India

Received 19 March 2012; Accepted 9 April 2012

Academic Editors: K. Cal and M. R. Jaafari

Copyright © 2012 Arvind Sharma and Sandeep Arora. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. Grassi, R. De Angelis, G. Lamanna, and C. Cervini, “The clinical features of rheumatoid arthritis,” European Journal of Radiology, vol. 27, no. 1, pp. S18–S24, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Ryan and P. Brooks, “Disease-modifying antirheumatic drugs,” Current Opinion in Rheumatology, vol. 11, no. 3, pp. 161–166, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Pincus, J. R. O'Dell, and J. M. Kremer, “Combination therapy with multiple disease-modifying antirheumatic drugs in rheumatoid arthritis: a preventive strategy,” Annals of Internal Medicine, vol. 131, no. 10, pp. 768–774, 1999. View at Scopus
  4. B. N. Cronstein, “The mechanism of action of methotrexate,” Rheumatic Disease Clinics of North America, vol. 23, no. 4, pp. 739–755, 1997. View at Publisher · View at Google Scholar · View at Scopus
  5. A. E. Van Ede, R. F. J. M. Laan, H. J. Blom, R. A. De Abreu, and L. B. A. Van de Putte, “Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity,” Seminars in Arthritis and Rheumatism, vol. 27, no. 5, pp. 277–292, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. J. R. O'Dell, “Methotrexate use in rheumatoid arthritis,” Rheumatic Disease Clinics of North America, vol. 23, no. 4, pp. 779–796, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. P. T. Condit, “On the site of action of amethopterin,” Science, vol. 134, no. 3488, p. 1421, 1961. View at Scopus
  8. G. C. Hwang, A. Y. Lin, W. Chen, and R. J. Sharpe, “Development and optimization of a methotrexate topical formulation,” Drug Development and Industrial Pharmacy, vol. 21, no. 17, pp. 1941–1952, 1995. View at Scopus
  9. K. Egbaria and N. Weiner, “Liposomes as a topical drug delivery system,” Advanced Drug Delivery Reviews, vol. 5, no. 3, pp. 287–300, 1990. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Sharma, V. kumar, V. Dhillon, A. Gupta, and S. Arora, “Evaluation of transdermal permeability of zidovudine entrapped in oleic acid vesicles Indo-Global Research,” Journal of Pharmaceutical Sciences, vol. 1, pp. 21–35, 2011.
  11. V. Dhillon, S. Sharma, S. Jain, A. Sharma, and S. Arora, “Formulation characterization and evaluation of new topical 5-fu by drug entrapment in oleic acid vesicles,” American Journal of PharmTech Research, vol. 1, pp. 1–16, 2011.
  12. M. Murakami, H. Yoshikawa, K. Takada, and S. Muranishi, “Effect of oleic acid vesicles on intestinal absorption of carboxyfluorescein in rats,” Pharmaceutical Research, vol. 3, no. 1, pp. 35–41, 1986. View at Scopus
  13. T. J. Franz, “Percutaneous absorption. On the relevance of in vitro data,” Journal of Investigative Dermatology, vol. 64, no. 3, pp. 190–195, 1975. View at Scopus
  14. R. R. Warner, M. C. Myers, and D. A. Taylor, “Electron probe analysis of human skin: determination of the water concentration profile,” Journal of Investigative Dermatology, vol. 90, no. 2, pp. 218–224, 1988. View at Scopus
  15. S. Jain, R. Sapre, A. K. Tiwary, and N. K. Jain, “Proultraflexible lipid vesicles for effective transdermal delivery of levonorgestrel: development, characterization, and performance evaluation.,” AAPS PharmSciTech, vol. 6, no. 3, pp. E513–E522, 2005. View at Scopus
  16. R. N. Saha, C. Sajeev, P. R. Jadhav, S. P. Patil, and N. Srinivasan, “Determination of celecoxib in pharmaceutical formulations using UV spectrophotometry and liquid chromatography,” Journal of Pharmaceutical and Biomedical Analysis, vol. 28, no. 3-4, pp. 741–751, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. G. D. Weinstein, J. L. McCullough, and E. Olsen, “Topical methotrexate therapy for psoriasis,” Archives of Dermatology, vol. 125, no. 2, pp. 227–230, 1989. View at Scopus
  18. M. J. Alvarez-Figueroa and J. Blanco-Méndez, “Transdermal delivery of methotrexate: iontophoretic delivery from hydrogels and passive delivery from microemulsions,” International Journal of Pharmaceutics, vol. 215, no. 1-2, pp. 57–65, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Trotta, E. Peira, F. Debernardi, and M. Gallarate, “Elastic liposomes for skin delivery of dipotassium glycyrrhizinate,” International Journal of Pharmaceutics, vol. 241, no. 2, pp. 319–327, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. M. J. Alvarez-Figueroa, M. B. Delgado-Charro, and J. Blanco-Méndez, “Passive and iontophoretic transdermal penetration of methotrexate,” International Journal of Pharmaceutics, vol. 212, no. 1, pp. 101–107, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Sharma, V. Dhillon, S. Sharma, S. Jain, and S. Arora, “Formulation characterization and evaluation of new topical 5-Fu by drug entrapment in oleic acid vesicles,” American Journal of PharmTech Research, vol. 1, no. 2, pp. 1–16, 2011.
  22. P. Loan Honeywell-Nguyen, A. M. De Graaff, H. W. Wouter Groenink, and J. A. Bouwstra, “The in vivo and in vitro interactions of elastic and rigid vesicles with human skin,” Biochimica et Biophysica Acta, vol. 1573, no. 2, pp. 130–140, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. B. A. I. Van Den Bergh, J. Vroom, H. Gerritsen, H. E. Junginger, and J. A. Bouwstra, “Interactions of elastic and rigid vesicles with human skin in vitro: electron microscopy and two-photon excitation microscopy,” Biochimica et Biophysica Acta, vol. 1461, no. 1, pp. 155–173, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. W. R. Hargreaves, “Liposomes from ionic, single-chain amphiphiles,” Biochemistry, vol. 17, no. 18, pp. 3759–3767, 1978. View at Scopus
  25. D. P. Cistola, J. A. Hamilton, D. Jackson, and D. M. Small, “lonization and phase behavior of fatty acids in water: application of the Gibbs phase rule,” Biochemistry, vol. 27, no. 6, pp. 1881–1888, 1988. View at Scopus
  26. P. Walde, T. Namani, K. Morigaki, and H. Hauser, “Formation and properties of fatty acid vesicles (liposomes),” in Liposome Technology, G. Gregoriadis, Ed., pp. 1–20, Informa Healthcare, New York, NY, USA, 3rd edition, 2007.
  27. C. L. Apel, D. W. Deamer, and M. N. Mautner, “Self-assembled vesicles of monocarboxylic acids and alcohols: conditions for stability and for the encapsulation of biopolymers,” Biochimica et Biophysica Acta, vol. 1559, no. 1, pp. 1–9, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. M. B. Dowling, J. H. Lee, and S. R. Raghavan, “pH-responsive jello: gelatin gels containing fatty acid vesicles,” Langmuir, vol. 25, no. 15, pp. 8519–8525, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. M. Gebicki and M. Hicks, “Ufasomes are stable particles surrounded by unsaturated fatty acid membranes,” Nature, vol. 243, no. 5404, pp. 232–234, 1973. View at Publisher · View at Google Scholar · View at Scopus
  30. P. L. Luisi, P. Walde, M. Blocher, and E. Blochliger, “Matrix effect in the size distribution of fatty acid vesicles,” The Journal of Physical Chemistry B, vol. 102, pp. 10383–10390, 1998.