Table 3: Solubility of AH in different chemical enhancers and release rate of formulations through dialysis membrane.

Formulation codeSolubilitya (mg/mL) Release rate (μg/cm2/hr1/2)

Control 1
CA1 1.13
CA2 1.25
CA3 1.83
CA4 1.18
CA5 1.08
CA6 1.43
CA7 1.32
CA8 1.51
CA9 0.89
CA10 1.22
CA11 1.63
CA12 1.82
CA13 1.53
CA14 1.15
CA15 1.40
CA16 1.73

aSolubility is the solubility of AH in the hydrogel solvent mixture at 25°C. is enhancement ratio of AH solubility over control solubility. Values represent mean ± S.D ( ).