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ISRN Pharmacology
Volume 2011 (2011), Article ID 949686, 7 pages
http://dx.doi.org/10.5402/2011/949686
Research Article

An Open-Label Pilot Study to Assess the Efficacy and Safety of Virgin Coconut Oil in Reducing Visceral Adiposity

1Healthy Lifestyle Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia
2Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kelantan 16150, Malaysia
3Department of Sport Sciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan 16150, Malaysia
4Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan 16150, Malaysia

Received 11 December 2010; Accepted 19 January 2011

Academic Editors: O. Badary, P. Cos, T. W. Stone, and T. B. Vree

Copyright © 2011 Kai Ming Liau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. This is an open-label pilot study on four weeks of virgin coconut oil (VCO) to investigate its efficacy in weight reduction and its safety of use in 20 obese but healthy Malay volunteers. Methodology. Efficacy was assessed by measuring weight and associated anthropometric parameters and lipid profile one week before and one week after VCO intake. Safety was assessed by comparing organ function tests one week before and one week after intake of VCO. Paired 𝑡 -test was used to analyse any differences in all the measurable variables. Results. Only waist circumference (WC) was significantly reduced with a mean reduction of 2.86 cm or 0.97% from initial measurement ( 𝑃 = . 0 2 ). WC reduction was only seen in males ( 𝑃 < . 0 5 ). There was no change in the lipid profile. There was a small reduction in creatinine and alanine transferase levels. Conclusion. VCO is efficacious for WC reduction especially in males and it is safe for use in humans.