About this Journal Submit a Manuscript Table of Contents
ISRN Pharmacology
Volume 2012 (2012), Article ID 410902, 6 pages
http://dx.doi.org/10.5402/2012/410902
Research Article

Nephroprotective Effect of Ursolic Acid in a Murine Model of Gentamicin-Induced Renal Damage

1Department of Pharmacology, Kasturba Medical College, Manipal University, Mangalore 575001, Karnataka, India
2Department of Pathology, K S Hegde Medical Academy, Nitte University, Deralakatte, Mangalore 574160, India
3Department of Physiology, Father Muller Medical College, Mangalore 575002, India

Received 4 April 2012; Accepted 3 May 2012

Academic Editors: J. L. Cornish and M. A. Prendergast

Copyright © 2012 Preethi G. Pai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. A. Swain and B. Kaplan-Machlis, “Therapeutic uses of vitamin E in prevention of atherosclerosis,” Alternative Medicine Review, vol. 4, no. 6, pp. 414–423, 1999. View at Scopus
  2. M. P. Mingeot-Leclercq and P. M. Tulkens, “Aminoglycoside neprotoxicity,” Antimicrobial Agents and Chemotherapy, vol. 43, no. 5, pp. 1003–1012, 1999.
  3. E. J. Begg and M. L. Barclay, “Aminoglycosides—50 years on,” British Journal of Clinical Pharmacology, vol. 39, no. 6, pp. 597–603, 1995. View at Scopus
  4. R. S. Edson and C. L. Terrell, “The aminoglycosides,” Mayo Clinic Proceedings, vol. 74, no. 5, pp. 519–528, 1999. View at Scopus
  5. B. J. Khoory, V. Fanos, A. Dall'Agnola, and L. Cataldi, “Aminoglycosides, risk factors and neonatal kidney,” Pediatria Medica e Chirurgica, vol. 18, no. 5, pp. 495–499, 1996. View at Scopus
  6. F. Rougier, D. Claude, M. Maurin, and P. Maire, “Aminoglycoside nephrotoxicity,” Current Drug Targets, vol. 4, no. 2, pp. 153–162, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Cuzzocrea, E. Mazzon, L. Dugo et al., “A role for superoxide in gentamicin-mediated nephropathy in rats,” European Journal of Pharmacology, vol. 450, no. 1, pp. 67–76, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. A. A. Al-Majed, A. M. Mostafa, A. C. Al-Rikabi, and O. A. Al-Shabanah, “Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats,” Pharmacological Research, vol. 46, no. 5, pp. 445–451, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. R. J. Reiter, D. X. Tan, R. M. Sainz, J. C. Mayo, and S. Lopez-Burillo, “Melatonin: reducing the toxicity and increasing the efficacy of drugs,” Journal of Pharmacy and Pharmacology, vol. 54, no. 10, pp. 1299–1321, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Halliwell and J. M. C. Gutteridge, Free Radicals in Biology and Medicine, Clarendon Press, Oxford, UK, 1999.
  11. K. V. Kumar, M. U. R. Naidu, A. A. Shifow, and K. S. Ratnakar, “Probucol protects against gentamicin-induced nephrotoxicity in rats,” Indian Journal of Pharmacology, vol. 32, no. 2, pp. 108–113, 2000. View at Scopus
  12. I. T. Abdel-Raheem, A. A. Abdel-Ghany, and G. A. Mohamed, “Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats,” Biological and Pharmaceutical Bulletin, vol. 32, no. 1, pp. 61–67, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Yaman and E. Balikci, “Protective effects of Nigella sativa against gentamicin-induced nephrotoxicity in rats,” Experimental and Toxicologic Pathology, vol. 62, no. 2, pp. 183–190, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. G. V. Harlalka, C. R. Patil, and M. R. Patil, “Protective effect of Kalanchoe pinnata pers. (Crassulaceae) on gentamicin-induced nephrotoxicity in rats,” Indian Journal of Pharmacology, vol. 39, no. 4, pp. 201–205, 2007. View at Scopus
  15. S. B. Mahato, S. K. Sarkar, and G. Poddar, “Triterpenoid saponins,” Phytochemistry, vol. 27, no. 10, pp. 3037–3067, 1988. View at Scopus
  16. J. Liu, “Pharmacology of oleanolic acid and ursolic acid,” Journal of Ethnopharmacology, vol. 49, no. 2, pp. 57–68, 1995. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Jain and A. K. Singhai, “Effect of Momordica dioica Roxb on gentamicin model of acute renal failure,” Natural Product Research, vol. 24, no. 15, pp. 1379–1389, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. R. P. Chandragouda, R. B. Jadhav, P. K. Singh, S. Mundada, and P. R. Patil, “Protective effect of oleanolic acid on gentamicin induced nephrotoxicity in rats,” Phytotherapy Research, vol. 24, no. 1, pp. 33–37, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. T. B. Mohammed and H. R. Sadeghnia, “Protective effect of safranal against gentamicin-induced nephrotoxicity in rat,” Iranian Journal of Medical Sciences, vol. 34, no. 4, pp. 285–288, 2009. View at Scopus
  20. L. O. Somova, A. Nadar, P. Rammanan, and F. O. Shode, “Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension,” Phytomedicine, vol. 10, no. 2-3, pp. 115–121, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. A. A. Shifow, K. V. Kumar, M. U. R. Naidu, and K. S. Ratnakar, “Melatonin, a pineal hormone with antioxidant property, protects against gentamicin-induced nephrotoxicity in rats,” Nephron, vol. 85, no. 2, pp. 167–174, 2000. View at Scopus
  22. A. O. Abdel-Zaher, M. M. Abdel-Rahman, M. M. Hafez, and F. M. Omran, “Role of nitric oxide and reduced glutathione in the protective effects of aminoguanidine, gadolinium chloride and oleanolic acid against acetaminophen-induced hepatic and renal damage,” Toxicology, vol. 234, no. 1-2, pp. 124–134, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. E. O. Farombi and M. Ekor, “Curcumin attenuates gentamicin-induced renal oxidative damage in rats,” Food and Chemical Toxicology, vol. 44, no. 9, pp. 1443–1448, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Balanehru and B. Nagarajan, “Protective effect of oleanolic acid and ursolic acid against lipid peroxidation,” Biochemistry International, vol. 24, no. 5, pp. 981–990, 1991. View at Scopus
  25. Y. A. Dominic and M. Subbaiyan, “Studies on mitochondrial lipid peroxidation in tumour-bearing rats treated with ursolic acid and ursolic acetate,” Medical Science Research, vol. 21, no. 5, pp. 213–215, 1993. View at Scopus
  26. X. H. Ma, Y. C. Zhao, L. Yin, R. L. Xu, D. W. Han, and M. S. Wang, “Studies on the preventive and therapeutic effects of ursolic acid (UA) on acute hepatic injury in rats,” Acta Pharmaceutica Sinica, vol. 21, no. 5, pp. 332–335, 1986. View at Scopus
  27. D. Beauchamp, G. Laurent, L. Grenier et al., “Attenuation of gentamicin-induced nephrotoxicity in rats by fleroxacin,” Antimicrobial Agents and Chemotherapy, vol. 41, no. 6, pp. 1237–1245, 1997. View at Scopus