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ISRN Pharmacology
Volume 2012 (2012), Article ID 580202, 8 pages
http://dx.doi.org/10.5402/2012/580202
Research Article

Characteristics and Prevalence of Latent Autoimmune Diabetes in Adults (LADA)

1Department of Pharmacology, L. J. Institute of Pharmacy, Sarkhej Gandhinagar Highway, Gujarat, Ahmedabad 380015, India
2Department of Pharmacology, L. M. College of Pharmacy, Navrangpura, Gujarat, Ahmedabad 380009, India
3Department of Endocrinology, Dia-Care Clinic, 2 Gandhi Park, Nehrunagar, Gujarat, Ahmedabad 380015, India
4Department of Pharmacology SPP School of Pharmacy & Technology Management, Mumbai 400056, India

Received 27 November 2011; Accepted 9 January 2012

Academic Editors: S. Cuzzocrea and K. Wada

Copyright © 2012 Priyanka P. Brahmkshatriya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes, one of the most commonly seen metabolic disorders, is affecting a major area of population in many developing as well as most of the developed countries and is becoming an alarming concern for the rising cost of the healthcare system. Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is less recognized and underdiagnosed type of diabetes which appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age at onset and initial response to oral hypoglycemic agents). An epidemiological study was carried out on 500 patients in the western region of India. Various parameters such as age at onset, duration of diabetes, gender, basal metabolic index (BMI), type of diabetes, family history, HbA1c levels, cholesterol levels, and current treatment regimen were evaluated and correlated with type 1 and type 2 diabetes. Moreover, diagnostic markers for LADA, namely, GAD autoantibodies and C-peptide levels, were determined for 80 patients selected from the epidemiological study. Some of the results obtained were found to be consistent with the literature whereas some results were found to be contradictory to the existing data.