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ISRN Pharmacology
Volume 2012 (2012), Article ID 789651, 7 pages
http://dx.doi.org/10.5402/2012/789651
Research Article

Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre

1Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand
2Division of Physiology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand
3Department of Animal Science, Faculty of Agricultural Technology, Chiang Mai Rajabhat University, Chiang Mai 50300, Thailand
4Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

Received 26 November 2011; Accepted 19 December 2011

Academic Editors: H. Cerecetto and A. Pittaluga

Copyright © 2012 Seewaboon Sireeratawong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We studied an acute and chronic oral toxicity of the extract from Ziziphus attopensis (ZA) in male and female SD rats according to the OECD guidelines. After a single oral administration of ZA 5 g/kg body weight, measurement of the body and organs, necropsy, and health monitoring were performed. The body and organ weights and behavior were not changed relative to the control rats indicating that ZA does not produce acute toxicity. The chronic toxicity was determined by oral feeding both male and female rats daily with ZA at the doses of 1, 2, 4, and 8 g/kg body weight for 180 days. Body weight changes, hematological and biochemical parameters, organ weights, gross finding, and histopathology examination were monitored during the experimental period. The results did not show any differences from the control groups. Analyses of these results with the information of signs, behavior, and health monitoring can lead to a conclusion that the long-term oral administration of ZA for 180 days does not cause chronic toxicity.