Table 3: Clinical blood chemistry values of female rats in chronic toxicity of ZA extract.

ControlZA extract
1 g/kg2 g/kg4 g/kg8 g/kga8 g/kgb

Glucose (mg/dL) 1 0 4 . 9 0 ± 4 . 9 4 1 0 0 . 4 0 ± 3 . 7 7 9 7 . 7 0 ± 2 . 9 4 9 8 . 0 0 ± 4 . 2 8 9 9 . 9 0 ± 6 . 2 5 1 0 3 . 5 0 ± 6 . 2 6
BUN (mg/dL) 1 8 . 9 0 ± 0 . 9 0 1 8 . 8 0 ± 0 . 9 9 1 9 . 3 0 ± 0 . 6 3 1 7 . 1 0 ± 0 . 9 6 1 7 . 0 0 ± 0 . 6 1 1 9 . 5 0 ± 0 . 7 0
Creatinine (mg/dL) 0 . 3 4 ± 0 . 0 2 0 . 3 5 ± 0 . 0 2 0 . 3 1 ± 0 . 0 1 0 . 3 1 ± 0 . 0 1 0 . 3 3 ± 0 . 0 1 0 . 3 9 ± 0 . 0 2
Total protein (g/dL) 5 . 1 5 ± 0 . 0 9 5 . 2 3 ± 0 . 1 7 5 . 1 9 ± 0 . 0 9 5 . 1 8 ± 0 . 0 5 5 . 2 1 ± 0 . 1 0 5 . 6 0 ± 0 . 1 0 *
Albumin (g/dL) 2 . 8 0 ± 0 . 0 7 2 . 7 4 ± 0 . 0 9 2 . 6 7 ± 0 . 0 5 2 . 7 2 ± 0 . 0 5 2 . 7 2 ± 0 . 0 6 2 . 9 8 ± 0 . 0 8
Total bilirubin (mg/dL) 0 . 1 2 ± 0 . 0 1 0 . 1 9 ± 0 . 0 4 0 . 1 9 ± 0 . 0 6 0 . 1 0 ± 0 . 0 0 0 . 1 3 ± 0 . 0 2 0 . 2 1 ± 0 . 0 3
Direct bilirubin (mg/dL) 0 . 0 5 ± 0 . 0 3 0 . 1 2 ± 0 . 0 6 0 . 1 3 ± 0 . 0 7 0 . 0 2 ± 0 . 0 1 0 . 0 7 ± 0 . 0 3 0 . 1 7 ± 0 . 0 4
SGOT (U/l) 1 4 5 . 0 0 ± 1 3 . 3 2 1 3 6 . 8 0 ± 1 1 . 2 1 1 4 8 . 5 0 ± 8 . 5 2 1 2 1 . 1 0 ± 1 2 . 8 0 1 6 0 . 7 0 ± 2 1 . 2 3 1 8 2 . 9 0 ± 1 6 . 9 2
SGPT (U/l) 4 9 . 0 0 ± 8 . 4 8 3 5 . 2 0 ± 1 . 4 4 4 3 . 3 0 ± 6 . 0 4 3 4 . 2 0 ± 3 . 5 2 4 3 . 9 0 ± 1 0 . 8 2 4 7 . 1 0 ± 5 . 3 8
ALP (U/l) 3 3 . 4 0 ± 1 . 3 3 3 6 . 0 0 ± 2 . 4 4 3 3 . 6 0 ± 1 . 9 8 3 6 . 2 0 ± 1 . 4 0 3 5 . 9 0 ± 2 . 1 5 3 1 . 8 0 ± 1 . 8 3

Values are expressed as mean ± SEM, 𝑛 = 1 0 .
*Significantly different from control, 𝑃 < 0 . 0 5 .
aA group was given ZA extract at 8 g/kg daily over 180 days.
bA satellite group was given ZA extract at 8 g/kg daily over 180 days followed by no treatment for 28 days.