Table 4: Significant contraindications.

AlprazolamKetoconazole, itraconazole, narrow-angle glaucoma, significant sleep apnea, myasthenia gravis, respiratory insufficiency, liver failure, and pregnancy
AmitriptylineRecent or concurrent MAOI use and acute myocardial infarction
Chloral hydrateHepatic or renal impairment, gastritis or ulcer, and severe cardiac disease
ClonazepamNarrow-angle glaucoma, significant sleep apnea, myasthenia gravis, respiratory insufficiency, liver failure, and pregnancy
DiazepamNarrow-angle glaucoma, significant sleep apnea, myasthenia gravis, respiratory insufficiency, liver failure, and pregnancy
DihenhydramineAcute asthma and breast-feeding
DoxepinRecent or concurrent MAOI use, narrow angle glaucoma, and urinary retention
EstazolamNarrow-angle glaucoma, significant sleep apnea, myasthenia gravis, respiratory insufficiency, liver failure, and pregnancy
Eszopiclone *
FlurazepamNarrow-angle glaucoma, significant sleep apnea, myasthenia gravis, respiratory insufficiency, liver failure, and pregnancy
LorazepamNarrow-angle glaucoma, significant sleep apnea, myasthenia gravis, respiratory insufficiency, liver failure, and pregnancy
MirtazepineRecent or concurrent MAOI use
NefazodoneActive liver disease, recent or concurrent MAOI use, acute myocardial infarction, concurrent use of carbamazepine, cisapride, or pimozide
NortriptylineRecent or concurrent MAOI use and acute myocardial infarction
OxazepamNarrow-angle glaucoma, significant sleep apnea, myasthenia gravis, respiratory insufficiency, liver failure, and pregnancy
Quetiapine *
RamelteonConcurrent fluvoxamine
TemazepamNarrow-angle glaucoma, significant sleep apnea, myasthenia gravis, respiratory insufficiency, liver failure, and pregnancy
Trazodone *
TriazolamKetoconazole, itraconazole, narrow-angle glaucoma, significant sleep apnea, myasthenia gravis, respiratory insufficiency, liver failure, and pregnancy
Zaleplon *
ZolpidemOSA, repiratory impairment, myasthenia gravis, severe hepatic impairment, and sleepwalking

Caffeine *
DexmethylphenidateAgitation, anxiety, glaucoma, motor tics, history of Tourette’s syndrome, and recent or concurrent MAOI use
DextroamphetamineSymptomatic cardiovascular/atherosclerotic disease, moderate or severe hypertension, hyperthyroidism, glaucoma, agitation, history of drug abuse, and recent or concurrent MAOI use
Dextroamphetamine and amphetamineSymptomatic cardiovascular/atherosclerotic disease, moderate or severe hypertension, hyperthyroidism, glaucoma, agitation, history of drug abuse, and recent or concurrent MAOI use
LisdexamfetamineSymptomatic cardiovascular/atherosclerotic disease, moderate or severe hypertension, hyperthyroidism, glaucoma, agitation, history of drug abuse, and recent or concurrent MAOI use
MethylphenidateAgitation, anxiety, glaucoma, motor tics, history of Tourette’s syndrome, and recent or concurrent MAOI use
Modafinil *

Gabapentin *
GHBAlcohol and other CNS depressants
Pramipexole *
Ropinirole *