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ISRN Rheumatology
Volume 2012 (2012), Article ID 415272, 4 pages
http://dx.doi.org/10.5402/2012/415272
Clinical Study

Anti-Ro52 Antibodies and Interstitial Lung Disease in Connective Tissue Diseases Excluding Scleroderma

1Unidade de Imunologia Clínica, Hospital de Santo António, Centro Hospitalar do Porto, 4099-001 Porto, Portugal
2Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal

Received 22 December 2011; Accepted 29 January 2012

Academic Editors: H. Ihn and C. G. Mackworth-Young

Copyright © 2012 João Pedro Ferreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Schulte-Pelkum, M. Fritzler, and M. Mahler, “Latest update on the Ro/SS-A autoantibody system,” Autoimmunity Reviews, vol. 8, no. 7, pp. 632–637, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. E. Ben-Chetrit, E. K. L. Chan, K. F. Sullivan, and E. M. Tan, “A 52-kD protein is a novel component of the SS-A/Ro antigenic particle,” Journal of Experimental Medicine, vol. 167, no. 5, pp. 1560–1571, 1988. View at Scopus
  3. E. K. L. Chan, J. C. Hamel, J. P. Buyon, and E. M. Tan, “Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen,” Journal of Clinical Investigation, vol. 87, no. 1, pp. 68–76, 1991. View at Scopus
  4. C. Defendenti, F. Atzeni, M. F. Spina et al., “Clinical and laboratory aspects of Ro/SSA-52 autoantibodies,” Autoimmunity Reviews, vol. 10, no. 3, pp. 150–154, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. M. B. Frank, K. Itoh, A. Fujisaku, P. Pontarotti, M. G. Mattei, and B. R. Neas, “The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome II, and its polymorphisms,” American Journal of Human Genetics, vol. 52, no. 1, pp. 183–191, 1993. View at Scopus
  6. D. A. Rhodes, G. Ihrke, A. T. Reinicke et al., “The 52 000 MW Ro/SS-A autoantigen in Sjögren's syndrome/systemic lupus erythematosus (Ro52) is an interferon-γ inducible tripartite motif protein associated with membrane proximal structures,” Immunology, vol. 106, no. 2, pp. 246–256, 2002. View at Publisher · View at Google Scholar
  7. S. A. Rutjes, W. T. M. Vree Egberts, P. Jongen, F. Van Den Hoogen, G. J. M. Pruijn, and W. J. Van Venrooij, “Anti-Ro52 antibodies frequently co-occur with anti-Jo-1 antibodies in sera from patients with idiopathic inflammatory myopathy,” Clinical and Experimental Immunology, vol. 109, no. 1, pp. 32–40, 1997. View at Scopus
  8. A. Granito, P. Muratori, L. Muratori et al., “Antibodies to SS-A/Ro-52kD and centromere in autoimmune liver disease: a clue to diagnosis and prognosis of primary biliary cirrhosis,” Alimentary Pharmacology and Therapeutics, vol. 26, no. 6, pp. 831–838, 2007. View at Publisher · View at Google Scholar · View at PubMed
  9. B. Hervier, M. Rimbert, F. Colonna, M. A. Hamidou, and M. Audrain, “Clinical significance of anti-Ro/SSA-52 kDa antibodies—a retrospective monocentric study,” Rheumatology, vol. 48, no. 8, pp. 964–967, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. P. Ghillani, C. André, C. Toly et al., “Clinical significance of anti-Ro52 (TRIM21) antibodies non-associated with anti-SSA 60kDa antibodies: results of a multicentric study,” Autoimmunity Reviews, vol. 10, no. 9, pp. 509–513, 2011. View at Publisher · View at Google Scholar · View at PubMed
  11. D. A. Rhodes and J. Trowsdale, “TRIM21 is a trimeric protein that binds IgG Fc via the B30.2 domain,” Molecular Immunology, vol. 44, no. 9, pp. 2406–2414, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. I. Peene, L. Meheus, S. De Keyser, R. Humbel, E. M. Veys, and F. De Keyser, “Anti-Ro52 reactivity is an independent and additional serum marker in connective tissue disease,” Annals of the Rheumatic Diseases, vol. 61, no. 10, pp. 929–933, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. R. La Corte, A. Lo Mo Naco, A. Locaputo, F. Dolzani, and F. Trotta, “In patients with antisynthetase syndrome the occurrence of anti-Ro/SSA antibodies causes a more severe interstitial lung disease,” Autoimmunity, vol. 39, no. 3, pp. 249–253, 2006. View at Publisher · View at Google Scholar · View at PubMed
  14. J. Sibilia, E. Chatelus, A. Meyer, J. E. Gottenberg, C. Sordet, and J. Goetz, “How can we diagnose and better understand inflammatory myopathies? The usefulness of auto-antibodies,” Presse Medicale, vol. 39, no. 10, pp. 1010–1025, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. A. Espinosa, V. Dardalhon, S. Brauner et al., “Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway,” Journal of Experimental Medicine, vol. 206, no. 8, pp. 1661–1671, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. M. C. Hochberg, “Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 40, no. 9, p. 1725, 1997. View at Scopus
  17. C. Vitali, S. Bombardieri, R. Jonsson et al., “Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group,” Annals of the Rheumatic Diseases, vol. 61, no. 6, pp. 554–558, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Hervier, M. Rimbert, F. Colonna, M. A. Hamidou, and M. Audrain, “Clinical significance of anti-Ro/SSA-52 kDa antibodies—a retrospective monocentric study,” Rheumatology, vol. 48, no. 8, pp. 964–967, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. D. M. Langguth, S. Morris, L. Clifford et al., “Specific testing for "isolated" anti-52 kDa SSA/Ro antibodies during standard anti-extractable nuclear antigen testing is of limited clinical value,” Journal of Clinical Pathology, vol. 60, no. 6, pp. 670–673, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. S. M. Levine, N. Raben, D. Xie et al., “Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis,” Arthritis and Rheumatism, vol. 56, no. 8, pp. 2729–2739, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus