Table 1: (a) Clinical, imaging, EMG, and EEG characteristics of individual APS NPSLE patients recorded at the time of the initial NP manifestation. (b) Clinical, imaging, EMG, and EEG characteristics of individual APS+ NPSLE patients recorded at the time of the initial NP manifestation.
(a)

IDAge of the patient at the time of NP event (years)Interval between NP event and SLE diagnosis (years)Case definitionBrain CT scan/brain MRI/EMG

1*16−2Generalized seizure disorder, acute psychosis, and severe hemicraneal headacheMRI: generalized cortical atrophy
2110Generalized seizure disorderNot available
3*300Generalized seizure disorderMRI: multiple focal deep white matter lesions hyperintense in T2-weighted images and FLAIR
4*170Generalized seizure disorderMRI: no abnormality
5*42−1Generalized seizure disorder, severe headache, major depressionMRI: subcortical high signal bifrontal, bilateral deep cortical, and corona radiata focal lesions in T2-weighted images.
6*230Generalized seizure disorder and ischemic strokeMRI: right cerebral atrophy. Left thalamic calcified lesion.
7490Ischemic strokeCT scan: ischemic infarct left hippocampus
8311Ischemic strokeCT scan: left lenticular haemorrhagic infarct
9502Ischemic strokeMRI: right ischemic parieto-temporal infarct
10230Peripheral neuropathyEMG: motor-sensitive neuropathy
11171Peripheral neuropathyEMG: motor-sensitive neuropathy
12*450Major depression, severe hemicraneal headacheMRI: multiple focal deep white matter high signal on T2-weighted images and FLAIR. Small focal lesions in the subcortical fronto parietal white matter, predominantly on the right.
13*292Major depression with suicidal ideation, cluster headacheMRI: multiple small focal subcortical white matter and right paramedian pontine high-signal lesions on T2-weighted images and FLAIR.

*Interictal EEG was performed in these patients. An epileptiform focus was detected in 3 (patients 3, 4, and 6) with no abnormality in the other 4 patients (patients 1, 5, 12, and 13). Nephritis was present in patients 3, 12, and 13 at the time of the NP event.
(b)

IDAge of the patient at the time of NP event (years)Interval between NP event and SLE diagnosis (years)ACR clinical entityAPS defining eventBrain CT scan/brain MRI/EMG

14295Ischemic stroke with hemorrhagic transformationCerebral thrombosisMRI: subcortical right parietal ischemic infarct with hemorrhagic transformation
153417Ischemic stroke Peripheral artery thrombosisMRI: right parietal ischemic infarct
16430Ischemic stroke and 7 days later Guillain Barré Syndrome Cerebral thrombosisMRI: oval-shaped left subcortical paraventricular high-signal lesions on T2- and FLAIR-weighted images with a signal change in diffusion sequence and a left corona hemorrhagic infarct; EMG: motor-sensitive polyneuropathy
17341Peripheral neuropathyCoronary thrombosisEMG: motor-sensitive neuropathy
183316Peripheral neuropathyRepeated dialysis access thrombosisEMG: motor-sensitive neuropathy
1938−2Major depression; ischemic optic neuropathy, Retinal artery thrombosisMRI: no abnormality
20*4314Major depressionLimb deep vein thrombosis and obstetric lossMRI: multiple focal subcortical lesions hyperintense in T2
21280Migrainous headaches and acute confusional state Cerebral thrombosisMRI: no abnormality
22*3514Severe headaches and cognitive dysfunction Obstetric lossMRI: multiple focal deep white matter lesions hyperintense in T2 on T2-weighted images and FLAIR.

*Interictal EEG was performed in 2 patients (patients 20 and 22). Left temporal subclinical rhythmic electrographic discharges of adults—SREDA was detected in patient 22.