Research Article

Development and Validation of RP-HPLC Method for Azilsartan Medoxomil Potassium Quantitation in Human Plasma by Solid Phase Extraction Procedure

Table 4

Results of matrix effect analysing 5 different lots of blank human plasma at three different levels of quality control samples.

LOT1.5  g/mL 4.5  g/mL 8.0  g/mL
MeanaRSD%Accuracy%MeanaRSD%Accuracy%MeanaRSD%Accuracy%

A-11.54 (±0.07 )4.48102.94.64 (±0.08)1.92103.18.29 (±0.28)3.43103.6
A-21.56 (±0.04)2.63104.54.86 (±0.07)1.64108.08.35 (±0.45)5.46104.4
A-31.49 (±0.02)1.19 99.64.72 (±0.10)2.23105.08.37 (±0.59)7.11103.1
A-41.52 (±0.05)3.20101.64.75 (±0.08)1.80105.78.51 (±0.45)5.36106.4
A-51.57 (±0.12)7.54104.74.72 (±0.12)2.58105.08.49 (±0.30)3.63106.1

a(±SD, g/mL).