Research Article
Development and Validation of RP-HPLC Method for Azilsartan Medoxomil Potassium Quantitation in Human Plasma by Solid Phase Extraction Procedure
Table 4
Results of matrix effect analysing 5 different lots of blank human plasma at three different levels of quality control samples.
| LOT | 1.5 g/mL | 4.5 g/mL | 8.0 g/mL | Meana | RSD% | Accuracy% | Meana | RSD% | Accuracy% | Meana | RSD% | Accuracy% |
| A-1 | 1.54 (±0.07 ) | 4.48 | 102.9 | 4.64 (±0.08) | 1.92 | 103.1 | 8.29 (±0.28) | 3.43 | 103.6 | A-2 | 1.56 (±0.04) | 2.63 | 104.5 | 4.86 (±0.07) | 1.64 | 108.0 | 8.35 (±0.45) | 5.46 | 104.4 | A-3 | 1.49 (±0.02) | 1.19 | 99.6 | 4.72 (±0.10) | 2.23 | 105.0 | 8.37 (±0.59) | 7.11 | 103.1 | A-4 | 1.52 (±0.05) | 3.20 | 101.6 | 4.75 (±0.08) | 1.80 | 105.7 | 8.51 (±0.45) | 5.36 | 106.4 | A-5 | 1.57 (±0.12) | 7.54 | 104.7 | 4.72 (±0.12) | 2.58 | 105.0 | 8.49 (±0.30) | 3.63 | 106.1 |
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a(±SD, g/mL).
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