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ISRN Surgery
Volume 2012 (2012), Article ID 394095, 6 pages
http://dx.doi.org/10.5402/2012/394095
Clinical Study

Sentinel Lymph Node Biopsy in Pure DCIS: Is It Necessary?

1Department of Surgery, Faculty of Medicine, Acıbadem University, Maltepe, 34848 Istanbul, Turkey
2Department of Pathology, Faculty of Medicine, Acıbadem University, 34848 Istanbul, Turkey
3Department of Radiology, Acıbadem Maslak Hospital, 34457 Istanbul, Turkey
4Department of Surgery, Acıbadem Maslak Hospital, 34457 Istanbul, Turkey

Received 12 February 2012; Accepted 4 March 2012

Academic Editors: D. Galetta, A. Petroianu, and A. Polydorou

Copyright © 2012 D. E. Boler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Sentinel lymph node biopsy (SLNB) in patients with pure ductal carcinoma in situ (DCIS) has been a matter of debate due to very low rate of axillary metastases. We therefore aimed to identify factors in a single institutional series to select patients who may benefit from SLNB. Material and Methods. Patients, diagnosed with pure DCIS ( 𝑛 = 6 3 ) between July 2000 and March 2011, were reviewed. All the sentinel lymph nodes were examined by serial sectioning (50 μm) of the entire lymph node and H&E staining, and by cytokeratin immunostaining in suspicious cases. Results. Median age was 51 (range, 30–79). Of 63 patients, 40 cases (63.5%) with pure DCIS underwent SLN, and 2 of them had a positive SLN (5%). In both 2 cases with SLN metastases, only one sentinel lymph node was involved with tumor cells. Patients who underwent SLNB were more likely to have a tumor size >30 mm or DCIS with intermediate and high nuclear grade or a mastectomy in univariate and multivariate analyses. Conclusion. In our series, we found a slightly higher rate of SLNB positivity in patients with pure DCIS than the large series reported elsewhere. This may either be due to the meticulous examination of SLNs by serial sectioning technique or due to our patient selection criteria or both.