Table 3: Univariate and multivariate Cox proportional hazards analysis of recurrence after primary transurethral resection for T1 bladder carcinoma in the southeast healthcare region in Sweden 1992–2001.

Univariate hazard ratio
(95% CI)
Multivariate hazard ratio
(95% CI)
value**

Tumor size
 ≤30 mm 1.01.0
 >30 mm 1.48 (1.09–2.03)1.51 (1.09–2.09)0.013
LVI*
 No1.01.0
 Suspected1.41 (0.98–2.04)1.31 (0.88–1.96)0.19
 Yes2.63 (1.48–4.66)2.65 (1.43–4.93)0.002
p16
 Abnormal1.01.0
 Normal0.84 (0.61–1.15)0.92 (0.66–1.27)0.61
Cyclin D1
 Abnormal1.01.0
 Normal0.91 (0.64–1.28)0.95 (0.67–1.37)0.80
p21
 Abnormal1.01.0
 Normal1.07 (0.75–1.53)1.18 (0.80–1.77)0.40
p53
 Abnormal1.01.0
 Normal1.71 (1.21–2.42)1.58 (1.09–2.28)0.015
MMP2
 Abnormal1.01.0
 Normal0.80 (0.55–1.16)0.79 (0.52–1.20)0.27
MMP9
 Abnormal1.01.0
 Normal0.69 (0.46–1.03)0.64 (0.42–0.99)0.046
pRb
 Abnormal1.01.0
 Normal0.92 (0.60–1.41) 1.00 (0.64–1.56) 1.0

*LVI: lymphovascular invasion.
** P values for variables are from multivariate Cox regression after adjusting for each other.