Table 4: Univariate and multivariate Cox proportional hazards analysis of progression after primary transurethral resection for T1 bladder carcinoma in the southeast healthcare region in Sweden 1992–2001.

Univariate hazard ratio
(95% CI)
Multivariate hazard ratio
(95% CI)
value**

Tumor size
 ≤30 mm 1.01.0
 >30 mm 1.28 (0.82–2.01) 1.32 (0.83–2.09) 0.24
LVI*
 No1.01.0
 Suspected0.99 (0.57–1.73) 0.91 (0.51–1.64)0.75
 Yes2.75 (1.40–5.41)3.41 (1.61–7.24) 0.001
p16
 Abnormal1.01.0
 Normal0.51 (0.31–0.83)0.46 (0.27–0.76)0.003
Cyclin D1
 Abnormal1.01.0
 Normal0.65 (0.41–1.04)0.82 (0.49–1.35) 0.43
p21
 Abnormal1.01.0
 Normal1.52 (0.88–2.64)1.43 (0.80–2.53) 0.23
p53
 Abnormal1.01.0
 Normal1.29 (0.78–2.13)1.41 (0.83–2.39)0.20
MMP2
 Abnormal1.01.0
 Normal0.90 (0.52–1.54)0.82 (0.47–1.45)0.50
MMP9
 Abnormal1.01.0
 Normal0.79 (0.45–1.39)0.89 (0.49–1.59)0.69
pRb
 Abnormal1.01.0
 Normal1.20 (0.66–2.18) 1.29 (0.70–2.38) 0.42

*LVI: lsymphovascular invasion.
** P values for variables are from multivariate Cox regression after adjusting for each other.