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ISRN Urology
Volume 2012 (2012), Article ID 391705, 7 pages
http://dx.doi.org/10.5402/2012/391705
Clinical Study

Three Years of Salvage IMRT for Prostate Cancer: Results of the Montpellier Cancer Center

1Département d’Oncologie Radiothérapie, CRLC Val d’Aurelle-Paul Lamarque, Montpellier 34298, France
2Département de Radio-Oncologie, Hôpital Maisonneuve-Rosemont, Montréal, QC, H1T 2M4, Canada
3Department of Urology, Clinique Beausoleil, Montpellier 34070, France

Received 4 December 2011; Accepted 3 January 2012

Academic Editor: M.-L. Hsieh

Copyright © 2012 Olivier Riou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. To assess the feasibility of salvage intensity-modulated radiation Therapy (IMRT) and to examine clinical outcome. Patients and Methods. 57 patients were treated with salvage IMRT to the prostate bed in our center from January, 2007, to February, 2010. The mean prescription dose was 68 Gy in 34 fractions. Forty-four patients received concomitant androgen deprivation. Results. Doses to organs at risk were low without altering target volume coverage. Salvage IMRT was feasible without any grade 3 or 4 acute gastrointestinal or urinary toxicity. With a median follow-up of 21 months, one grade 2 urinary and 1 grade 2 rectal late toxicities were reported. Biological relapse-free survival was 96.5% (2.3% (1/44) relapsed with androgen suppression and 7.7% (1/13) without). Conclusion. Salvage IMRT is feasible and results in low acute and chronic side-effects. Longer follow-up is warranted to draw conclusions in terms of oncologic control.