Table 1: Human matrix metalloproteinases (MMPs).

No.MMPMMP classEnzymeMolecular weight (kDa)Substrates

1MMP-1CollagenasesCollagenase-157*
47 A
Collagens (I, II, III, VII, and X), proteoglycans, entactin, ovostatin, MMP-2, MMP-9
2MMP-8CollagenasesCollagenase-2/neutrophil collagenase85*
64 A
Collagens (I, II, III, VII, VIII, and X), fibronectin, proteoglycans
3MMP-13CollagenasesCollagenase-360*
48 A
Collagens (I, II, III, VII, VIII, and X), tenascin, plasminogen, aggrecan, fibronectin, osteonectin, MMP-9
4MMP-18CollagenasesCollagenase-453*
51 A
Type I collagen
5MMP-2GelatinasesGelatinase-A72*
66 A
Gelatin, collagen (IV, V, VII VI, IX, and X), elastin, fibronectin
6MMP-9GelatinasesGelatinase-A92*
86 A
Collagens (IV, V, VII, X, and XIV), gelatin, entactin, elastin, fibronectin, osteonectin, plasminogen, proteoglycans
7MMP-3StromelysinsStromelysin-I60*
52 A
Collagens (IV, V, and IX), gelatin, aggrecan, laminin, elastin, casein, osteonectin, fibronectin, ovostatin, entactin, plasminogen
8MMP-10StromelysinsStromelysin-253*
47 A
Collagens (I, II, IV, and V), gelatin, casein, elastin, fibronectin
9MMP-11StromelysinsStromelysin-260*
47 A
Collagens (IV, V, IX, and X), laminin, elastin, fibronectin, casein, proteoglycans
10MMP-17StromelysinsHomology tostromelysin-265*
63 A
Pro-MMP2, fibrin/fibrinogen, gelatin
11MMP-7MatrisylinsMatrisylin28*
19 A
Collagen IV, gelatin, fibronectin, laminin, elastin, casein, transferrin
12MMP-26MatrisylinsMatrisylin-229Collagen IV, fibronectin, fibrinogen, gelatin, pro-MMP9
13MMP-14MT-MMP (membrane type-MMP)MT1-MMP66*
54 A
Collagens (I, II, III), gelatin, fibronectin, laminin, vitronectin, entactin, pro-MMP-2
14MMP-15MT-MMPMT2-MMP76Fibronectin, gelatin, vitronectin, entactin, laminin, pro-MMP-2
15MMP-16MT-MMPMT3-MMP65*
63 A
Collagen III, gelatin, casein, fibronectin, pro-MMP-2
16MMP-17MT-MMPMT4-MMP65*
63 A
Pro-MMP-2, fibrinogen, gelatin
17MMP-24MT-MMPMT5-MMP73Fibronectin, pro-MMP-2, proteoglycans, gelatin
18MMP-25MT-MMPMT6-MMP62Pro-MMP-2, pro-MMP-9, collagen IV, gelatin, fibronectin, proteinase A
19MMP-12Other enzymesMacrophage metalloelastase54*
45 A
Collagen IV, gelatin, elastin, casein, fibronectin, vitronectin, laminin, entactin, fibrin/fibrinogen
20MMP-19Other enzymesRASI I59Collagen (I, IV) gelatin, fibronectin, laminin
21MMP-20Other enzymesEnamelysin56Amelogenin, aggrecan
22MMP-21Other enzymes65
23MMP-22Other enzymes58*
53 A
24MMP-23Other enzymes44Gelatin
25MMP-27Other enzymes59
26MMP-28Other enzymesEpilysin59

*Zymogen molecular weight; A: active form molecular weight.