Table 2: Correlation between MMP levels and clinicopathologic parameters. NA: not available; T: tissue; B: blood; U: urine.

AuthorB/T/UPat/ConMethodExpres.tmStageGradeRecurrencePrognosisMMP-

Gohji et al. [4]B146/52Enzyme assayIncreasedNANAYesNAMMP-2
MMP-3
Angulo et al. [65]B31/11RT-PCRIncreasedIncreasedNANANAMMP-2
MMP-9
TIMP-2
Szarvas et al. [50]B97/22Enzyme assayIncreasedNANANAYesMMP-7
Vasala et al. [10]B84/—ELISADecreasedNANANAYespro-MMP-2
MMP-2
TIMP-2
Tasci et al. [67]B102/94PCR lymphocytesIncreasedIncreasedIncreasedNANAMMP-1
Offersen et al. [68]U188/—Immunocapture activity assayIncreasedIncreasedIncreasedYesYesMMP-9
Szarvas et al. [69]U132/96Enzyme assayIncreasedNANANAYesMMP-7
Hoque et al. [70]U175RT-PCRMethylationIncreasedNANAYesTIMP-3
Eissa et al. [71]U136/60ELISA Gelatin zymographyIncreasedNAIncreasedNANAMMP-2
MMP-9
TIMP-2
Di Carlo et al. [73]U25/—Gelatin zymographyIncreasedIncreasedIncreasedNANAMMP-9
Davies et al. [55]T42/7In situ hybridIncreasedIncreasedNANAYesMMP-2
MMP-9
Grignon et al. [56]T42/—IHQIncreasedIncreasedNANAYesTIMP-2
Kanayama et al. [51]T41/—RT-PCRIncreasedIncreasedNANAYesMMP-2
TIMP-2
Papathoma et al. [57]TGelatin zymography IHQNANANANAYesMMP-2
MMP-9
Hara et al. [61]T51Northern blot analysisNAIncreasedIncreasedYesNAMMP-9
TIMP-2