Table 2: Mean and median values with ranges for age, tPSA, %fPSA, prostate volume, PSAD, and number of positive (suspicious) DREs in all, PCa, and NEM patients for both cohorts.

VariableExternal validation cohort“ProstataClass” cohort+P value
All
𝑛 = 2 8 2
PCa
𝑛 = 1 0 1
NEM
𝑛 = 1 8 1
All
𝑛 = 7 9 8
PCa
𝑛 = 4 6 8
NEM
𝑛 = 3 3 0

Age (years)
 Mean666767646366
 Median67*68*66*646366<0.0005
 Range46–8350–8246–8338–8543–7938–85
tPSA (ng/mL)
 Mean6.846.836.857.548.775.81
 Median6.666.666.796.637.754.690.387
 Range4.01–9.994.01–9.614.06–9.990.49–27.040.86–24.020.49–27.04
%fPSA (%)
 Mean15.6713.1417.114.8411.3019.86
 Median15.0*12.0*16.0*12.7510.2718.310.002
 Range4.0–48.05.0–30.04.0–48.02.52–69.393.10–49.862.52–69.39
Volume (mL)
 Mean42.6234.1447.3543.737.252.9
 Median37.6529.943.8383445.50.900
 Range7.1–1717.1–10015–17110–18010–11013–180
PSAD (tPSA/Vol.)
 Mean0.1970.2420.1720.2110.2760.120
 Median0.1740.2210.1540.1570.2240.0860.030
 Range0.04–0.800.05–0.800.04–0.550.01–1.350.03–1.350.01–1.00
No. pos. DRE (%)67 (23.8%)*37 (36.6%)*30 (16.6%)*314 (39.3%)284 (60.7%)30 (9.1%)<0.0005

+ PSA and %fPSA of “ProstataClass” cohort using the Beckman Access assay.
*Significantly different from “ProstataClass” cohort.