Table 3: ROC curve analysis for tPSA, %fPSA, ANNs, and nomograms.

Parameter cohorttPSA%fPSAKarakiewicz et al.’s Nomogram IKawakami et al.’s Nomogram II ANN-Charité

Area under the ROC curve (AUC)

Saarow cohort0.5010.6690.7130.742*0.694
“ProstataClass” cohort0.70.782

Specificity at 95% sensitivity

Saarow cohort3.96%12.9%30.4%18.2%18.8%
“ProstataClass” cohort27.8%27.5%

Specificity at 90% sensitivity

Saarow cohort6.93%25.7%40.9%27.1%33.7%
“ProstataClass” cohort39.4%44.1%

*Significantly different from %fPSA.