About this Journal Submit a Manuscript Table of Contents
ISRN Urology
Volume 2012 (2012), Article ID 763159, 6 pages
http://dx.doi.org/10.5402/2012/763159
Review Article

Pharmacotherapy in Pediatric Neurogenic Bladder Intravesical Botulinum Toxin Type A

Urology Department, Hospital de Pediatría S.A.M.I.C. “Prof. Dr. Juan P. Garrahan”, Combate de los Pozos No. 1881 (CPA: C 1245 AAM), Buenos Aires, Argentina

Received 7 March 2012; Accepted 5 April 2012

Academic Editors: D. Minardi and J. Walter

Copyright © 2012 Cristian Sager et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

When the neurogenic bladder is refractory to anticholinergics, botulinum toxin type A is used as an alternative. The neurotoxin type A reduces bladder pressure and increases its capacity and wall compliance. Additionally, it contributes to improving urinary continence and quality of life. This novel therapy is ambulatory with a low incidence of adverse effects. Due to its transitory effect, it is necessary to repeat the injections in order to sustain its therapeutic effect. In these review article we talk about Mechanism of Action, Indications, effects, administration and presentations of the Botulinum Neurotoxin Type A in pediatric patients. Also, we make references to controversial issues surrounding its use. A bibliographic search was done selecting articles and revisions from Pubmed. The key words used were botulinum toxin A, neurogenic bladder, and children. The search was limited to patients younger than 18 years of age and reports written in English in the past ten years.