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ISRN Urology
Volume 2013 (2013), Article ID 351309, 4 pages
http://dx.doi.org/10.1155/2013/351309
Research Article

The Effect of Erythropoietin on Ischemia/Reperfusion Injury after Testicular Torsion/Detorsion: A Randomized Experimental Study

1Department of Urology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran
2Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran
3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran

Received 11 February 2013; Accepted 7 March 2013

Academic Editors: W. Krause and V. Serretta

Copyright © 2013 Fahimeh Kazemi Rashed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. X. Schneck and M. E. Bellinger, “Abnormalities of the testis and scrotum and their surgical management,” in Campbell-Walsh Urology, A. J. Wein, L. R. Kavoussi, A. C. Novick, A. W. Partin, and C. A. Peters, Eds., vol. 4, WB Saunders, Philadelphia, Pa, USA, 9th edition, 2007.
  2. M. Saba, C. R. Morales, E. De Lamirande, and C. Gagnon, “Morphological and biochemical changes following acute unilateral testicular torsion in prepubertal rats,” Journal of Urology, vol. 157, no. 3, pp. 1149–1154, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. J. M. McCord, “Oxygen-derived free radicals in postischemic tissue injury,” The New England Journal of Medicine, vol. 312, no. 3, pp. 159–163, 1985. View at Scopus
  4. N. Paschos, M. G. Lykissas, and A. E. Beris, “The role of erythropoietin as an inhibitor of tissue ischemia,” International Journal of Biological Sciences, vol. 4, no. 3, pp. 161–168, 2008. View at Scopus
  5. C. J. Parsa, A. Matsumoto, J. Kim et al., “A novel protective effect of erythropoietin in the infarcted heart,” Journal of Clinical Investigation, vol. 112, no. 7, pp. 999–1007, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Ergun, A. Koc, K. Dolapcioglu et al., “The protective effect of erythropoietin and dimethylsulfoxide on ischemia-reperfusion injury in rat ovary,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 152, no. 2, pp. 186–190, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Carelli, G. Marfia, A. M. Di Giulio, G. Ghilardi, and A. Gorio, “Erythropoietin: recent developments in the treatment of spinal cord injury,” Neurology Research International, vol. 2011, Article ID 453179, 8 pages, 2011. View at Publisher · View at Google Scholar
  8. M. Karaca, F. Odabasoglu, Y. Kumtepe, A. Albayrak, E. Cadirci, and O. N. Keles, “Protective effects of erythropoietin on ischemia/reperfusion injury of rat ovary,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 144, no. 2, pp. 157–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. K. Shishavan, M. Sayyah-Melli, J. S. Rad, and L. Roshangar, “The ovario-protective effect of erythropoietin against oxidative damage associated with reperfusion following ovarian torsion in rat,” American Journal of Animal and Veterinary Sciences, vol. 107, supplement 2, p. S223, 2009. View at Scopus
  10. X. Liu, J. Shen, Y. Jin, M. Duan, and J. Xu, “Recombinant human erythropoietin (rhEPO) preconditioning on nuclear factor-κ B (NF-κB) activation & proinflammatory cytokines induced by myocardial ischaemia-reperfusion,” Indian Journal of Medical Research, vol. 124, no. 3, pp. 343–354, 2006. View at Scopus
  11. D. W. Johnson, B. Pat, D. A. Vesey, Z. Guan, Z. Endre, and G. C. Gobe, “Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure,” Kidney International, vol. 69, no. 10, pp. 1806–1813, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. V. Bakan, H. Çıralık, F. I. Tolun, Y. Atli, A. Mil, and Ş. Öztürk, “Protective effect of erythropoietin on torsion/detorsion injury in rat model,” Journal of Pediatric Surgery, vol. 44, no. 10, pp. 1988–1994, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Köseoǧlu, E. Yilmaz, K. Ceylan, E. Uzun, I. Bayram, and F. Hizli, “The protective effect of erythropoietin infusion on testicular torsion/ detorsion: an experimental study,” International Urology and Nephrology, vol. 41, no. 1, pp. 85–91, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Yazihan, H. Ataoglu, N. Koku, E. Erdemli, and A. K. Sargin, “Protective role of erythropoietin during testicular torsion of the rats,” World Journal of Urology, vol. 25, no. 5, pp. 531–536, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Akcora, M. E. Altug, T. Kontas, and E. Atik, “The protective effect of darbepoetin alfa on experimental testicular torsion and detorsion injury,” International Journal of Urology, vol. 14, no. 9, pp. 846–850, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. M. H. Ozkan, I. M. Vural, S. Moralioglu, S. Uma, and Y. Sarioglu, “Torsion/detorsion of the testis does not modify responses to nitric oxide in rat isolated penile bulb,” Basic and Clinical Pharmacology and Toxicology, vol. 101, no. 2, pp. 117–120, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. S. G. Johnsen, “Testicular biopsy score count–a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males,” Hormones, vol. 1, no. 1, pp. 2–25, 1970. View at Scopus
  18. M. J. Cosentino, M. Nishida, R. Rabinowitz, and A. T. K. Cockett, “Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion,” Journal of Andrology, vol. 7, no. 1, pp. 23–31, 1986. View at Scopus
  19. M. Foller, L. Kaestner, E. Straface, and J. Vogel, “Erythrocytes and erythropoietin,” International Journal of Cell Biology, vol. 2011, Article ID 972536, 2 pages, 2011. View at Publisher · View at Google Scholar
  20. N. S. A. Patel, E. J. Sharples, S. Cuzzocrea et al., “Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo,” Kidney International, vol. 66, no. 3, pp. 983–989, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Dobashi, K. Goda, H. Maruyama, and M. Fujisawa, “Erythropoietin gene transfer into rat testes by in vivo electroporation may reduce the risk of germ cell loss caused by cryptorchidism,” Asian Journal of Andrology, vol. 7, no. 4, pp. 369–373, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. B. U. Ergur, M. Kiray, C. Pekcetin, H. A. Bagriyanik, and G. Erbil, “Protective effect of erythropoietin pretreatment in testicular ischemia-reperfusion injury in rats,” Journal of Pediatric Surgery, vol. 43, no. 4, pp. 722–728, 2008. View at Publisher · View at Google Scholar · View at Scopus