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ISRN Urology
Volume 2013 (2013), Article ID 786545, 6 pages
http://dx.doi.org/10.1155/2013/786545
Research Article

ERG Protein Expression Is of Limited Prognostic Value in Men with Localized Prostate Cancer

1Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, AB, Canada T2V 1P9
2Department of Urology, University of Calgary, Calgary, AB, Canada T2N 1N4
3The Prostate Cancer Center, Calgary, AB, Canada T2V 1P9
4Department of Oncology, Biochemistry and Molecular Biology, Calgary, AB, Canada T2N 1N4
5Southern Alberta Cancer Institute and Tom Baker Cancer Center, Calgary, AB, Canada T2N 1N4

Received 4 June 2013; Accepted 27 June 2013

Academic Editors: J. H. Ku, T. Nelius, and T. Nishiyama

Copyright © 2013 Liang Hong Teng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The prognostic significance of ERG expression in prostate cancer (PCA) has generated mixed results. We sought to investigate the prognostic significance of ERG expression in a localized cohort of men with PCA. Material and Methods. We investigated ERG protein expression in a cohort of 198 men with localized PCA. ERG expression was correlated with patients' clinical outcome and several pathological parameters, including Gleason score (GS), pathological stage, surgical margin, and extra-capsular extension. Results. ERG expression was detected in 86/198 (43.4%) patients exclusively in neoplastic epithelium. Overall, ERG mean expression intensity was versus in acinar PCA compared to foamy type PCA ( ). In HGPIN, ERG intensity levels were comparable to those in foamy type PCA ( ) but significantly lower than those in acinar PCA ( ). ERG expression was significantly associated with extra-prostatic extension and higher pathological stage and showed a trend toward seminal vesicle invasion. Herein, ERG expression was documented in 50/131 (38.1%) patients with pT2 versus 30/55 (54.5%) patients with pT3 ( ). ERG association with higher pathological stage was more pronounced in patients with . Grouping patients into those with versus 7, there was no significant association between ERG expression and GS. Similarly, no association was present in relation to either surgical margins or postsurgical serum PSA levels. Conclusion. We report significant association between ERG protein levels and extra-prostatic extension and higher pathological stage. ERG expression is not associated with adverse clinical outcome and is of limited prognostic value in localized PCA.