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ISRN Veterinary Science
Volume 2012 (2012), Article ID 802308, 6 pages
Research Article

Extracellular Proteins of Mycoplasma synoviae

1Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, CCB, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil
2Embrapa Swine and Poultry Research Center, Animal Health Laboratory, 89700-000 Concordia, SC, Brazil

Received 21 July 2012; Accepted 9 August 2012

Academic Editors: D. Barnard, E. Bártová, and A. Shamay

Copyright © 2012 Manuel Sebastián Rebollo Couto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mycoplasma synoviae is a Gram positive bacteria lacking of cell wall that affects chickens and turkeys causing infection in the upper respiratory tract and in some cases arthritis, with economical impact to broiler breeders. Treatment and prevention of avian synovitis depend on knowledge of the infectious process. Secreted or surface-exposed proteins play a critical role in disease because they often mediate interactions between host and pathogen. In the present work, we sought to identify possible M. synoviae secreted proteins by cultivating the bacteria in a modified protein-free Frey medium. Using this approach, we were able to detect in the cell-free fraction a number of proteins that have been shown in other organisms to be secreted, suggesting that they may also be secreted by M. synoviae.