Table 1: Change of body weight during the experimental period.

BWSham controlVehicle controlCAPTP 31.25P 62.5P 125LOSA

Day 0(1) 1 8 1 . 6 3 ± 8 . 2 8 1 8 2 . 5 0 ± 1 0 . 4 2 1 8 3 . 3 8 ± 6 . 9 5 1 7 9 . 7 5 ± 6 . 1 4 1 8 0 . 2 5 ± 6 . 2 5 1 7 8 . 7 5 ± 6 . 8 4 1 7 8 . 2 5 ± 7 3 2 7
Day 1(2) 1 6 4 . 3 8 ± 7 . 1 9 1 6 6 . 7 5 ± 7 . 8 0 1 6 5 . 5 0 ± 6 . 4 8 1 6 2 . 7 5 ± 5 . 8 5 1 6 2 . 6 3 ± 5 . 4 5 1 6 4 . 0 0 ± 5 . 1 8 1 6 2 . 2 5 ± 5 . 6 0
Day 7 2 0 2 . 1 3 ± 1 5 . 1 6 2 0 6 . 7 5 ± 1 2 . 4 3 2 0 3 . 2 5 ± 6 . 6 7 2 0 0 . 5 0 ± 1 3 . 3 8 1 9 7 . 2 5 ± 1 0 . 2 5 1 9 8 . 0 0 ± 1 0 . 8 0 1 9 8 . 3 8 ± 7 . 9 1
Day 14 2 1 5 . 7 5 ± 1 6 . 1 8 2 2 1 . 7 5 ± 1 2 . 3 4 2 1 6 . 5 0 ± 1 1 . 1 1 2 1 8 . 5 0 ± 1 4 . 3 0 2 1 7 . 1 3 ± 1 0 . 8 3 2 1 1 . 8 8 ± 7 . 0 8 2 1 3 . 2 5 ± 9 . 8 1
Day 21 2 3 3 . 8 8 ± 2 5 . 1 6 2 4 0 . 6 3 ± 1 4 . 3 8 2 2 8 . 3 8 ± 1 1 . 5 4 2 3 2 . 5 0 ± 1 4 . 8 5 2 3 6 . 5 0 ± 1 5 . 5 7 2 2 8 . 8 8 ± 9 . 3 3 2 2 6 . 2 5 ± 9 . 4 7
Day 27 2 4 1 . 1 3 ± 2 4 . 0 9 2 4 9 . 1 3 ± 2 2 . 9 7 2 2 9 . 6 3 ± 1 5 . 6 4 2 3 7 . 8 8 ± 1 3 . 2 3 2 3 9 . 8 8 ± 1 3 . 0 4 2 3 9 . 2 5 ± 8 . 4 8 2 3 6 . 5 0 ± 1 1 . 4 8
Day 28(3) 2 2 6 . 7 5 ± 2 2 . 2 6 2 3 4 . 1 3 ± 2 0 . 3 6 2 2 2 . 5 0 ± 1 1 . 0 6 2 2 4 . 3 8 ± 1 3 . 6 2 2 2 7 . 8 8 ± 1 2 . 8 0 2 2 4 . 7 5 ± 6 . 0 9 2 2 3 . 5 0 ± 9 . 0 6
Day 32 2 5 1 . 3 8 ± 2 4 . 2 0 2 2 3 . 5 0 ± 2 4 . 1 4 2 2 2 . 3 8 ± 1 6 . 6 6 ** 2 3 0 . 8 8 ± 2 1 . 9 6 2 3 2 . 8 8 ± 1 5 . 9 6 2 3 0 . 8 8 ± 6 . 4 5 ** 2 2 2 . 0 0 ± 1 0 . 8 6 *
Day 33(4) 2 3 1 . 5 0 ± 2 5 . 4 0 2 1 2 . 8 8 ± 2 2 . 2 5 2 0 9 . 7 5 ± 1 5 . 2 5 2 1 5 . 0 0 ± 2 0 . 0 7 2 1 9 . 6 3 ± 1 2 . 7 3 2 1 7 . 6 3 ± 1 0 . 9 5 2 0 7 . 7 5 ± 8 . 1 5 **

𝑛 = 8 ; (Mean ± S.D., g); (1)One day before of test article administration; (2)first administration of test article after overnight fasted; (3)At CDDP-administration day after overnight fasted; (4)At euthanasia; * 𝑃 < 0 . 0 1 and ** 𝑃 < 0 . 0 5 compared to sham by MW test.